Does the doping strategy of ferrite nanoparticles create a correlation between reactivity and toxicity?
Does the doping strategy of ferrite nanoparticles create a correlation between reactivity and toxicity?
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DOI：
10.1039/d3en00076a
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发表时间：
2023-04-11
影响因子：
7.3
通讯作者：
Misra, Superb K.
中科院分区：
文献类型：
--
作者：
Chakraborty, Swaroop;Menon, Dhruv;Misra, Superb K.
由于其在电阻率，化学稳定性和饱和磁化强度方面的显着性能，铁氧体纳米颗粒正越来越多地用于广泛的应用。本研究旨在研究铁氧体纳米颗粒是否可以安全可行地掺杂过渡金属元素，而不会对纳米颗粒的稳定性和毒性产生不利影响。使用湿化学路线合成具有9-11 nm尺寸范围的铁氧体（MxFe 3-xO 4，其中M = Co、Cu、Zn、Mn）的单分散和相纯变体。对于所有掺杂剂，铁氧体内的掺杂%在15-18%的范围内。与铁氧体纳米颗粒相比，Co和Mn掺杂显著增强了溶解，而Cu和Zn掺杂对溶解具有相反的效果。对铁氧体进行DFT计算以计算Fe和掺杂剂原子的空位形成能证实了实验溶解数据。A549细胞表现出剂量依赖性反应（10-200 μ g mL（-1）），细胞活力的降低遵循MnxFe 3-xO 4> CoxFe 3-xO 4> ZnxFe 3-xO 4> CuxFe 3-xO 4> Fe 3 O 4的趋势。溶解，细胞活力和摄取之间的相关性研究表明，细胞活力和溶解有很强的负相关性Fe 3 O 4，和CoxFe 3-xO 4，而CuxFe 3-xO 4这种相关性是非常弱的。最后，我们提供了一个概述的掺杂对其他金属氧化物纳米粒子（CuO，ZnO，TiO 2和CeO 2）的安全性的影响相比，铁氧体纳米粒子。
Owing to their remarkable properties in terms of electrical resistivity, chemical stability, and saturation magnetisation, ferrite nanoparticles are being increasingly used for a wide range of applications. This study looks to investigate as to whether ferrite nanoparticles can be safely and viably doped with transition metal elements without adversely affecting the stability and toxicity of the nanoparticles. Monodispersed and phase pure variants of ferrites (MxFe3-xO4 where M = Co, Cu, Zn, Mn) were synthesised with a size range of 9-11 nm using a wet chemistry route. The doping % within the ferrites was within the range of 15-18% for all the dopants. Compared to ferrite nanoparticles, Co and Mn doping significantly enhanced the dissolution, whereas doping with Cu and Zn had an opposite effect to dissolution. DFT calculations performed on the ferrites to calculate the vacancy formation energy of Fe and dopant atoms substantiated the experimental dissolution data. A549 cells showed a dose dependent response (10-200 mu g mL(-1)) and the reduction in cell viability followed the trend of MnxFe3-xO4 > CoxFe3-xO4 > ZnxFe3-xO4 > CuxFe3-xO4 > Fe3O4. A correlation study between dissolution, cell viability and uptake indicated cell viability and dissolution had a strong negative correlation for Fe3O4, and CoxFe3-xO4 whereas for CuxFe3-xO4 this correlation was very weak. We conclude by providing an overview of the impact of doping on the safety of other metal-oxide nanoparticles (CuO, ZnO, TiO2 and CeO2) in comparison to ferrite nanoparticles.