THE STRUCTURE OF THE POLYCYCLIC NONADECAPEPTIDE RO-09-0198
THE STRUCTURE OF THE POLYCYCLIC NONADECAPEPTIDE RO-09-0198
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DOI：
10.1002/hlca.19880710811
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发表时间：
1988-01-01
影响因子：
1.8
通讯作者：
KAMIYAMA, T
中科院分区：
文献类型：
--
作者：
KESSLER, H;STEUERNAGEL, S;KAMIYAMA, T
肽抗生素Ro 09-0198的氨基酸序列的常规测定通过经由侧链的四个环化来阻止。在最高领域和自动Edman降解的NMR光谱的联合应用产生了一个完整的测定的连接模式。从NOE数据得到的三维结构表现出一个有趣的分离的氨基酸与亲水性和疏水性侧链。
The conventional determination of the amino-acid sequence of the peptide antibiotic Ro 09-0198 was prevented by four cyclizations via side chains. The joint application of NMR spectroscopy at highest field and automated Edman degradation yielded a complete determination of the connectivity pattern. The three-dimensional structure derived from NOE data exhibits an interesting separation of amino acids with hydrophilic and hydrophobic side chains.