Facile synthesis of copper doping hierarchical hollow porous hydroxyapatite beads by rapid gelling strategy
Facile synthesis of copper doping hierarchical hollow porous hydroxyapatite beads by rapid gelling strategy
复制标题
通过快速凝胶策略轻松合成铜掺杂分级中空多孔羟基磷灰石珠
DOI：
10.1016/j.msec.2019.110531
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Liang Tongxiang
中科院分区：
文献类型：
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作者：
Yang Hui;Zhang Dong;Peng Wenkun;Di Yao;Gao Huichang;Liang Tongxiang
磷酸钙基陶瓷材料广泛应用于骨组织工程。迄今为止，通过简单易行且可规模化的生产策略构建单分散多孔磷酸钙微球仍然是一个尚未解决的挑战。本文中，使用快速胶凝策略来将瓜尔胶和金属氢氧化物联合收割机组合，这有助于制备中空分级多孔羟基磷灰石珠。结果表明，铜离子浓度和煅烧温度对产物的微观结构变化有较大影响。较高浓度的铜离子导致中空结构的生长，这些陶瓷珠表现出优异的生物相容性和抗菌性能。系统地研究了产物的结构演变，并提出了形成机理。
Calcium phosphate based ceramic materials are widely used in bone tissue engineering. Till now, it remains an unmet challenge to construct monodispersed hollow porous calcium phosphate beads through facile and scalable-production strategy. Herein, a rapid gelling strategy is used to combine the guar gum and metal hydroxide, which helps to prepare hollow hierarchical porous hydroxyapatite beads. Results show that the concentration of copper ions and calcination temperature greatly affect the microstructure transformation of the product. Higher concentrations of copper ions lead to the growth of hollow structures, and these ceramic beads exhibit excellent biocompatibility and antibacterial properties. The structure evolution of the products is systematically investigated, and a formation mechanism has been proposed.