Total heart volume variation throughout the cardiac cycle in humans
Total heart volume variation throughout the cardiac cycle in humans
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DOI：
10.1152/ajpheart.01125.2003
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发表时间：
2004-07-01
影响因子：
4.8
通讯作者：
Arheden, H
中科院分区：
文献类型：
--
作者：
Carlsson, M;Cain, P;Arheden, H
心动周期期间心脏总容积（心房加心室）的变化影响心脏泵送的效率。本研究的目的是使用MRI确认健康志愿者心动周期期间心脏总容积变异的存在、程度和贡献者。8名健康志愿者在休息时进行MRI检查。使用以下方法计算整个心动周期内心脏总容积的变化：1）来自梯度回波电影图像的面积测量和2）流量敏感序列，以量化所有通往和来自心脏的血管中的流量。心脏收缩期最大心脏总容量减少8.2 +/- 0.8%（SEM，范围4.8-10.6%），通过方法1测量，8.8 +/- 1.0%（SEM，范围5.6-11.8%），方法之间具有良好的一致性[根据Bland-Altman分析的差异为-0.6% +/- 1.0%（SD），组内相关系数= 0.999]。这种体积的减少主要是由心脏最宽直径处心中水平的变化解释的，其中左侧占优势。在心脏短轴上，层容积的变化与舒张末期层容积的变化成正比。本研究证实了心脏总容积变异的存在，主要发生在房室平面运动区域和左侧。总心脏体积变化可以涉及心脏使用能量的效率，以最小化周围组织的位移，同时考虑在心室收缩期间将血液吸入心房所需的能量。
Variations in total heart volume (atria plus ventricles) during a cardiac cycle affect efficiency of cardiac pumping. The goals of this study were to confirm the presence, extent, and contributors of total heart volume variation during the cardiac cycle in healthy volunteers with the use of MRI. Eight healthy volunteers were examined by MRI at rest. Changes in total cardiac volume throughout the cardiac cycle were calculated using the following methods: 1) planimetry derived from gradient-echo cine images and 2) flow-sensitive sequences to quantify flow in all vessels leading to and from the heart. The maximum total heart volume diminished during systole by 8.2 +/- 0.8% (SEM, range 4.8-10.6%) measured by method 1 and 8.8 +/- 1.0% (SEM, range 5.6-11.8%) by method 2 with good agreement between the methods [difference according to Bland-Altman analysis -0.6% +/- 1.0% (SD), intraclass correlation coefficient = 0.999]. This decrease in volume is predominantly explained by variation at the midcardiac level at the widest diameter of the heart with a left-sided predominance. In the short axis of the heart, the change of slice volume was proportional to the end-diastolic slice volume. The present study has confirmed the presence of total heart volume variation that predominantly occurs in the region of atrioventricular plane movement and on the left side. The total heart volume variation may relate to the efficiency of energy use by the heart to minimize displacement of surrounding tissue while accounting for the energy required to draw blood into the atria during ventricular systole.