SEROLOGICAL EVIDENCE FOR SIMULTANEOUS OCCURRENCES OF LYME-DISEASE AND BABESIOSIS
SEROLOGICAL EVIDENCE FOR SIMULTANEOUS OCCURRENCES OF LYME-DISEASE AND BABESIOSIS
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DOI：
10.1093/infdis/152.3.473
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发表时间：
1985-01-01
影响因子：
6.4
通讯作者：
GIRON, JA
中科院分区：
文献类型：
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作者：
BENACH, JL;COLEMAN, JL;GIRON, JA
莱姆病的螺旋体病原体-田鼠巴氏疏螺旋体和伯氏疏螺旋体都是通过蜱虫-达米尼硬蜱传播的。血清学证据表明，54%的巴贝斯虫病患者测试有IgG和IgM抗体的螺旋体引起莱姆病。同样，66%随机选择的莱姆病患者来自两种疾病的流行地区，但不是来自不发生巴贝虫病的地区，也有B的IgM和IgG抗体。显微镜抗原交叉反应性不是这些发现的原因，因为实验动物实验感染了B。田鼠不产生抗B的抗体。burgdorferi，并且用来自螺旋体纯培养物的生物体免疫的实验室动物不产生针对B的抗体。显微镜我们认为，这些患者同时暴露于这两种生物体的双重感染蜱媒。
Babesia microti and Borrelia burgdorferi, the spirochetal agent of Lyme disease, are both transmitted by the tick Ixodes dammini. Serological evidence has shown that 54% of the patients with babesiosis tested have IgG and IgM antibodies to the spirochete causing Lyme disease. Likewise, 66% of randomly selected patients with Lyme disease from geographic areas endemic for both diseases, but not from areas where babesiosis does not occur, also have IgM and IgG antibodies to B. microti. Antigenic cross-reactivity is not the reason for these findings, as laboratory animals experimentally infected with B. microti do not develop antibodies tO B. burgdorferi, and laboratory animals immunized with organisms derived from pure cultures of spirochetes do not develop antibodies to B. microti. We suggest that these patients are concurrently exposed to both organisms by doubly infected tick vectors.