Lung dendritic cell-epithelial cell crosstalk in Th2 responses to allergens.
Lung dendritic cell-epithelial cell crosstalk in Th2 responses to allergens.
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DOI：
10.1016/j.coi.2011.09.008
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发表时间：
2011-12
影响因子：
7
通讯作者：
M. Willart;H. Hammad
中科院分区：
文献类型：
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作者：
M. Willart;H. Hammad
树突状细胞（DC）已被证明是负责启动和维持适应性Th2反应在哮喘。越来越清楚的是，DC功能受到与邻近细胞如上皮细胞的串扰的强烈影响，其可以释放许多促进Th2应答的先天性细胞因子。临床相关的过敏原经常直接或间接地干扰气道上皮细胞和DC的先天免疫功能。更好地理解这些相互作用可能会导致更好的预防，并最终导致哮喘的新治疗方法。
Dendritic cells (DC) have been shown to be responsible for the initiation and maintenance of adaptive Th2 responses in asthma. It is increasingly clear that DC functions are strongly influenced by crosstalk with neighboring cells like epithelial cells, which can release a number of innate cytokines promoting Th2 responses. Clinically relevant allergens often interfere directly or indirectly with the innate immune functions of airway epithelial cells and DC. A better understanding of these interactions might lead to a better prevention and ultimately to new treatments for asthma.