VALUE OF LUNG CANCER DETECTION BY 6-MONTHLY CHEST RADIOGRAPHS
VALUE OF LUNG CANCER DETECTION BY 6-MONTHLY CHEST RADIOGRAPHS
复制标题
DOI：
10.1136/thx.23.4.414
复制
发表时间：
1968-01-01
期刊：
影响因子：
10
通讯作者：
BRETT, GZ
中科院分区：
文献类型：
--
作者：
BRETT, GZ
结果报告的一项前瞻性研究，进行了大规模放射照相服务的西北大都市区的目的是评估早期肺癌检测的六个月的胸部X光片。研究人员将29,723名40岁及以上男性的肺癌经历与25,311名仅在研究开始和结束时接受X光片检查的对照组进行了比较。在试验组中，29，416名男性（98.9%）和对照组中，25，044名男性（99%）接受了随访。分析了实现这一结果所采用的方法。对实验组进行的半年一次的调查发现了65例肺癌，年发病率和检出率为0.9%.。这些病例中，65%被切除。在试验组的所有肺癌病例中，无论其检测来源如何，43.6%可手术，而对照组为29%。差异有统计学意义（P= 0.03）。根据试验组62例死亡和对照组59例死亡计算的肺癌年死亡率分别为0.7 ‰和0.8 ‰。得出的结论是，由于早期发现的六个月胸部X光片并没有显着降低死亡率从肺癌的危险人口，这样的大规模调查的政策，男性在癌症年龄似乎是不合理的，但是，通过这种方法越来越多地发现可切除的肺癌，这为鼓励高血压患者提供了合理的基础，鼓励高危人士经常使用现有的集体射线照相设施。
Results are reported of a prospective study, carried out by the Mass Radiography Service of the North-West Metropolitan Region for the purpose of evaluating early lung cancer detection by six-monthly chest radiographs. The lung cancer experience of a test group of 29,723 men aged 40 and over who were offered six-monthly chest radiographs over a period of three years is compared with a similarly constituted control group of 25,311 men who were radiographed only at the beginning and the end of the study. In the test group 29,416 men (98·9%) and in the control group 25,044 men (99%) were followed up. The methods employed to achieve this result are analysed. The six-monthly surveys of the test group yielded 65 cases of lung cancer, giving an annual incidence and detection rate of 0·9 per thousand examined. Of these cases 65% were resected. Of all cases of lung cancer in the test group, irrespective of their source of detection, 43·6% were operable, compared with 29% in the control group. The difference (P=0·03) is statistically significant. The annual mortality rate from lung cancer based on 62 deaths in the test group and 59 deaths in the control was 0·7 and 0·8 per thousand respectively. The conclusions are reached that since early detection by six-monthly chest radiographs has not significantly reduced the mortality from lung cancer in a population at risk, a policy of such large-scale surveys of men in the cancer age would not seem justified, but that the increased discovery of resectable lung cancer by this method forms a reasonable basis for encouraging individuals in high-risk groups to make regular use of existing mass radiography facilities.