Lymphokine-activated killer (LAK) cell phenomenon. IV. Lysis by LAK cell clones of fresh human tumor cells from autologous and multiple allogeneic tumors.
Lymphokine-activated killer (LAK) cell phenomenon. IV. Lysis by LAK cell clones of fresh human tumor cells from autologous and multiple allogeneic tumors.
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淋巴因子激活杀伤（LAK）细胞现象。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
S. A. Rosenberg
中科院分区：
文献类型：
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作者：
Anthony A. Rayner;E. A. Grimm;Michael T. Lotze;Debra J. Wilson;S. A. Rosenberg
Activated killer cells are generated by the incubation of peripheral blood mononuclear leukocytes (PBL) in the lymphokine interleukin 2 (IL-2). Unseparated populations of these lymphokine-activated killer (LAK) cells lyse a variety of fresh noncultured human tumor targets, but they do not kill normal PBL. This study analyzed the generation and lytic specificity of LAK cell clones. Of 49 (84%) clones isolated by limiting-dilution techniques from a whole population of LAK cells, 41 manifested significant LAK cell activity. LAK cell clones had varied cell surface phenotypes. Clones with high and intermediate LAK cell activity were Leu 2+3-4+7-DR+Tac+ and Leu 2-3+4+7-DR+Tac+, respectively. Single LAK cell clones lysed multiple fresh human tumor targets including autologous sarcoma, 5 allogeneic sarcomas, and a colon cancer in addition to the cultured cell line K562. Autologous PBL were not lysed. Tumor targets were each lysed by multiple LAK cell clones. Sixteen subclones were derived from 5 of these LAK cell clones. These subclones had 99% or greater probability of being derived from a single cell. These subclones also exhibited lysis of multiple tumor targets. These findings suggest the existence of a shared determinant, expressed by multiple human tumors, which is recognized in common by multiple LAK cell clones.
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HNK-1 (Leu-7) 人淋巴细胞的表征。
DOI：
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发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Abo,T;Balch,CM
通讯作者：
Balch,CM
活化的 HNK-1 颗粒淋巴细胞表达白细胞介素 2 受体：其增殖的必要条件。
DOI：
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发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Abo,T;Miller,CA;Balch,CM;Cooper,MD
通讯作者：
Cooper,MD
产生源自人外周血“空细胞”部分的克隆 NK 细胞系。
DOI：
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发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Hercend,T;Meuer,S;Reinherz,EL;Schlossman,SF;Ritz,J
通讯作者：
Ritz,J
人类自然杀伤细胞克隆系的细胞表面表型。
DOI：
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发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Kornbluth,J;Flomenberg,N;Dupont,B
通讯作者：
Dupont,B