Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions
Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions
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DOI：
10.1016/0925-4773(95)00464-5
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发表时间：
1996-01-01
影响因子：
2.6
通讯作者：
Zimmer, A
中科院分区：
文献类型：
--
作者：
Hellmich, HL;Kos, L;Zimmer, A
我们描述了小鼠胶质细胞源性神经营养因子（GDNF）基因的克隆及其在胚胎发育过程中的表达。GDNF是TGF-β相关基因超家族的远亲成员，最初是基于其显著的神经营养活性而鉴定的。GDNF在E7.5和E10.5之间的神经发生的早期阶段在前神经外胚层中以高度动态的模式表达。从E10.5开始，GDNF也在通过诱导上皮-间充质相互作用发育的几个器官中表达。在这些器官中，GDNF表达严格限于间充质组织，而在上皮中没有发现。我们的研究结果表明GDNF在神经元发育的早期阶段和上皮间质相互作用中具有多种作用。
We describe the cloning of the mouse glial cell line-derived neurotrophic factor (GDNF) gene and its expression during embryogenesis. GDNF is a distant member of the superfamily of TGF-beta related genes that was originally identified on the basis of its striking neurotrophic activity. GDNF is expressed in a highly dynamic pattern in the anterior neuroectoderm during early stages of neurogenesis between E7.5 and E10.5. Beginning at E10.5 GDNF is also expressed in several organs that develop through inductive epithelial-mesenchymal interactions. In those organs, GDNF expression is strictly confined to mesenchymal tissues and is not found in epithelia. Our results suggest multiple roles for GDNF during early stages of neuronal development and in epithelial-mesenchymal interactions.