Apoptosis in animal models of virus-induced disease.

Apoptosis in animal models of virus-induced disease.
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DOI:
10.1038/nrmicro2071
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发表时间:
2009-02
期刊:
Nature reviews. Microbiology
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其他
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细胞凋亡与病毒诱导的人类中枢神经系统、心脏和肝脏疾病有关,并导致大量的发病率和死亡率。尽管病毒诱导的细胞凋亡在细胞培养物中的单个细胞中得到了很好的表征,但体内病毒诱导的细胞凋亡以及细胞凋亡在病毒诱导的疾病中的作用还没有很好地建立。本综述重点关注病毒诱导的中枢神经系统、心脏和肝脏疾病的动物模型,这些模型为细胞凋亡在发病机制中的作用、相关途径和潜在的治疗意义提供了见解。
Apoptosis is associated with virus-induced human diseases of the central nervous system, heart and liver, and causes substantial morbidity and mortality. Although virus-induced apoptosis is well characterized in individual cells in cell culture, virus-induced apoptosis in vivo and the role of apoptosis in virus-induced disease is not well established. This Review focuses on animal models of virus-induced diseases of the central nervous system, heart and liver that provide insights into the role of apoptosis in pathogenesis, the pathways involved and the potential therapeutic implications.
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