Positive feedback circuits and memory
Positive feedback circuits and memory
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DOI：
10.1016/s0764-4469(00)00112-8
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发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
Thomas, R
中科院分区：
文献类型：
--
作者：
Demongeot, L;Kaufman, M;Thomas, R
调节反馈回路的概念是指系统中各元件之间的定向循环相互作用。有两类电路，正电路和负电路，它们的性质形成了鲜明的对比。正电路是多稳态（多稳态）发生的先决条件，因此，它们涉及所有显示滞后或记忆的过程。内生或外生扰动可以导致系统表现出或唤起一个特定的稳定状态。正回路在细胞分化和免疫学中的作用是有据可查的。负回路参与稳态调节，有或没有振荡。本文的目的是表明：a）正回路解释了狭义记忆的许多特征（即，神经记忆和记忆唤起）以及大感觉（例如分化或免疫记忆）;和B）正和负回路的简单组合提供了强大的调节模块，其也可以在电池中相关联。这些实体在神经生物学领域以及在分化和免疫学领域中具有巨大的动力学可能性。在这里，我们考虑一个通用的最小的监管模块，我们建议采用术语“逻辑调节子”，它可以被认为是一个原子的雅各布整合子。它包括一个积极的和一个消极的电路在其相互作用矩阵，我们还记得这些电路的同时存在的主要结果。最后，我们给出了这类相互作用矩阵的三个应用。前两个亲爱的共存的多个稳定的稳态和周期性的分化和免疫系统显示滞后特性。第三部分讨论了海马记忆唤起过程神经模型的同步化和去同步化的双重问题。(C)2000年科学院/科学和医学版Elsevier SAS。
The concept of regulatory feedback circuit refers to oriented cyclic interactions between elements of a system. There are two classes of circuits, positive and negative, whose properties are in striking contrast. Positive circuits are a prerequisite for the occurrence of multiple steady states (multistationarity), and hence, they are involved in all processes showing hysteresis or memory. Endogenous or exogenous perturbations can lead the system to exhibit or to evoke one particular stable regime. The role of positive circuits in cell differentiation and in immunology is well documented. Negative circuits are involved in homeostatic regulation, with or without oscillations. The aim of th is paper is to show: a) that positive circuits account for many features of memory stricto sensu (i.e., neural memory and mnesic evocation) as well as large sensu (e.g. differentiation or immunological memory); and b) that simple combinations of positive and negative circuits provide powerful regulatory modules, which can also be associated in batteries, These entities have vast dynamical possibilities in the field of neurobiology, as well as in the fields of differentiation and immunology. Here we consider a universal minimal regulatory module, for which we suggest to adopt the term 'logical regulon', which can be considered as an atom of Jacob's integron. It comprises a positive and a negative circuit in its interaction matrix, and we recall the main results related to the simultaneous presence of these circuits. Finally, we give three applications of this type of interaction matrix. The first two dear with the coexistence of multiple stable steady states and periodicity in differentiation and in an immunological system showing hysteretic properties. The third deals with the dual problems of synchronization and desynchronization of a neural model for hippocampus memory evocation processes. (C) 2000 Academie des sciences/Editions scientifiques et medicales Elsevier SAS.