Coupled oxygen transport analysis in the avascular wall of a coronary artery stenosis during angioplasty
Coupled oxygen transport analysis in the avascular wall of a coronary artery stenosis during angioplasty
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DOI：
10.1016/j.jbiomech.2007.09.011
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Back, Lloyd H.
中科院分区：
文献类型：
--
作者：
Banerjee, Rupak K.;Kwon, Ohwon;Back, Lloyd H.
通过求解对流-扩散方程，数值研究了冠状动脉狭窄血管壁内的耦合氧输运。两个几何形状复制狭窄之前和之后，经皮腔内冠状动脉成形术（PTCA）用于分析。比较结果以评价狭窄程度对氧转运的影响。重要的生理方面，如在壁中的氧消耗，由血红蛋白携带的氧，血液的非牛顿粘度，以及来自血管的氧供应都包括在内。结果表明，动脉壁内侧区域的PO 2近似于10 mmHg。在流动加速区，流向壁面的氧通量增大，而在流动再附着区，流向壁面的氧通量减小。在流动分离的位置附近，氧通量有一个小的上升，然后急剧下降。在PTCA前狭窄的血流再附着点处，到壁的氧通量的下降是PTCA后狭窄的四倍。无血管壁中的最小PO 2，PO 2，（min），在该位置分别降低至与PTCA后和PTCA前狭窄的6.0和4.2 mmHg相似。在血流再附着点，术前PTCA的PO 2，（w）和PO 2，（min）的下降与术后PTCA狭窄的2倍相似。因此，本研究量化了心血管介入治疗前后向动脉壁的氧转运。(c)2007爱思唯尔有限公司保留所有权利。
The coupled oxygen transport in the avascular wall of a coronary artery stenosis is studied numerically by solving the convection-diffusion equations. Two geometries replicating stenosis before and after percutaneous transluminal coronary angioplasty (PTCA) are used for the analysis. The results are compared to evaluate the effect of the degree of stenosis on oxygen transport. Important physiological aspects, such as oxygen consumption in the wall, oxygen carried by the hemoglobin, non-Newtonian viscosity of the blood, and supply of oxygen from the vasa vasorum are included. The results show that the PO2 in the medial region of the arterial wall is similar to 10 mmHg. The oxygen flux to the wall increases in the flow acceleration region, whereas it decreases at the flow reattachment zone. Near the location of flow separation, there is a small rise followed by a sharp fall in the oxygen flux. The drop in the oxygen flux to the wall at the point of flow reattachment for pre-PTCA stenosis is four times that for post-PTCA stenosis. The minimum PO2 in the avascular wall, PO2,(min), at this location decreases to similar to 6.0 and 4.2 mmHg for post- and pre-PTCA stenosis, respectively. The drop in PO2,(w) and PO2,(min) at the point of flow reattachment for pre-PTCA is similar to 2 times that for post-PTCA stenosis. Thus, the present study quantifies the oxygen transport to the arterial wall before and after cardiovascular intervention. (c) 2007 Elsevier Ltd. All rights reserved.