Effects of anxiety on TNF-α levels during psychological stress
Effects of anxiety on TNF-α levels during psychological stress
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DOI：
10.1016/j.jpsychores.2007.03.001
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发表时间：
2007-07-01
影响因子：
4.7
通讯作者：
Vikram, Yeragani K.
中科院分区：
文献类型：
--
作者：
Chandrashekara, S.;Jayashree, K.;Vikram, Yeragani K.
目的：心理应激可影响免疫系统，从而导致应激相关疾病。本研究探讨心理应激和应对技巧对血浆细胞因子水平的影响。材料和方法：一百八十三名学生，在一个学年的不同阶段，参加了这项研究。测量血浆肿瘤坏死因子α（TNF-α）、白细胞介素（IL）-2可溶性受体α和IL-4，并检查其与焦虑[状态焦虑量表（SAI）]和贝尔适应量表关键词：心理应激;焦虑;免疫;细胞因子;应对（BAI）评分的关系。结果如下：与新入学的学生（FAS）相比，期中考试学生（NITS）和考试学生（ETS）的SAI得分显著更高。此外，TNF-α水平在ETS的高焦虑组和低焦虑组之间存在显著差异，但在NITS或FAS中没有差异。在ETS组中，SAI分数和BAI情绪分数之间的相关性最高。结论：ETS组焦虑水平高者TNF-α水平显著低于对照组，且具有情境特异性。(C)2007年由Elsevier Inc.出版
Objectives: Psychological stress can influence the immune system, which may result in stress-related illnesses. In this study, we investigated the effect of psychological stress and the coping skill on plasma cytokine levels. Materials and methods: One hundred eighty-three students, at different stages of an academic year, participated in this study. Plasma tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-2 soluble receptor alpha, and IL-4 were measured and examined in relation to the measures of anxiety [State Anxiety Inventory (SAI)] and Bell Adjustment Inventory Keywords: Psychological stress; Anxiety; Immunity; Cytokines; Coping (BAI) score. Results: SAI scores were significantly higher in both midterm students (NITS) and examination-taking students (ETS), compared with the freshly admitted students (FAS). In addition, TNF-alpha levels were significantly different between the high- and the low-anxiety groups of ETS but not in NITS or FAS. The correlation between SAI scores and the BAI emotional scores was highest in the ETS group. Conclusions: TNF-ct level was significantly lower in the ETS group with high anxiety scores, and it is situation specific. (C) 2007 Published by Elsevier Inc.