Genetics of Head circumference in Infancy : A Longitudinal Study of Japanese Twins
Genetics of Head circumference in Infancy : A Longitudinal Study of Japanese Twins
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婴儿期头围遗传学：日本双胞胎的纵向研究
DOI：
10.1002/ajhb.21190
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发表时间：
2011
影响因子：
2.9
通讯作者：
Yokoyama Y
中科院分区：
文献类型：
--
作者：
Silventoinen K;Karvonen M;Sugimoto M;Kaprio J;Dunkel L;Yokoyama Y
目的以往的研究表明，头围（HC）有很强的遗传影响，但对婴儿期HC的遗传病因学发展知之甚少，特别是在非高加索人群中。因此，我们决定分析遗传HC增长在日本infants.MethodsLongitudinal措施HC可从出生到13个月的年龄在206单卵和156双卵完全双胞胎对。双胞胎data.ResultsWe的遗传建模发现只有很少的证据表明性别特异性差异的遗传HC，从而分析了男孩和女孩在一起。5个月后的年龄HC的遗传力是高的，但在此之前的年龄也存在大量的共同的环境成分。HC不仅具有很强的遗传持久性，而且还出现了新的遗传变异。新的环境变化共享的co-twins影响HC被发现，直到3个月的年龄，这种影响被进一步传递，直到1岁的age.ConclusionsHC和它的增长是强烈的遗传调节。不同年龄的HC变异受相同的遗传因素影响，在出生后的第一年出现了新的遗传变异。关于HC变异中遗传成分的知识可能有助于设计工具，用于在基于人群的相关疾病筛查中定义HC的异常生长。Am. J.生物学，2011.© 2011 Wiley利斯公司
ObjectivesPrevious studies have shown strong genetic influence to head circumference (HC), but still little is known on the development of genetic etiology of HC in infancy, especially in non‐Caucasian populations. Thus, we decided to analyze the genetics of HC growth in Japanese infants.MethodsLongitudinal measures of HC were available from birth to 13 months of age in 206 monozygotic and 156 dizygotic complete twin pairs. Genetic modeling for twin data was used.ResultsWe found only little evidence for sex‐specific differences in the genetics of HC and thus analyzed boys and girls together. After 5 months of age the heritability of HC was high, but before that age also a substantial common environmental component was present. Not only strong genetic persistence for HC was found but also a new genetic variation emerged. New environmental variation shared by co‐twins affecting HC was found until 3 months of age, and this effect was further transmitted until 1 year of age.ConclusionsHC and its growth are strongly genetically regulated. Largely, the same genetic factors affect the variation of HC at different ages, and new genetic variation emerged during the first year of life. Knowledge on the genetic component in the variation of HC may help to design tools for defining abnormal growth of HC in population‐based screenings for related disorders. Am. J. Hum. Biol., 2011. © 2011 Wiley‐Liss, Inc.