Microcalcification detection using cone-beam CT mammography with a flat-panel imager
Microcalcification detection using cone-beam CT mammography with a flat-panel imager
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DOI：
10.1088/0031-9155/49/11/005
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发表时间：
2004-06-07
影响因子：
3.5
通讯作者：
Glick, SJ
中科院分区：
文献类型：
--
作者：
Gong, X;Vedula, AA;Glick, SJ
本研究的目的是调查微钙化可检出性使用CT乳腺摄影与平板成像。为了实现这一点，开发了一个计算机模拟模型的非晶硅，碘化铯为基础的平板成像系统使用线性级联模型。乳房被建模为半椭圆形形状，具有50%脂肪和50%腺体组织的组成。微钙化被建模为具有碳酸钙组成的小球。结果表明，平均腺体剂量相当于通常使用的双视图筛选乳腺X射线摄影，CT乳腺X射线摄影与平板探测器能够提供图像，其中大多数微钙化是可检测的。五名物理学家观察员观看模拟CT乳房X光摄影重建，进行了接受者操作特征（ROC）研究。结果表明，直径等于或大于0.175 mm的微钙化可以检测到与ROC曲线下的平均面积（AUC）大于0.95使用0.1或0.2 mm像素化探测器。结果还表明，最佳的检测器的像素大小是0.2毫米左右的微钙化检测，基于微钙化的可检测性和数据采集和重建所需的时间之间的权衡。
The purpose of this study was to investigate microcalcification delectability using CT mammography with a flat-panel imager. To achieve this, a computer simulation was developed to model an amorphous-silicon, CsI based flat-panel imager system using a linear cascaded model. The breast was modelled as a hemi-ellipsoid shape with composition of 50% adipose and 50% glandular tissue. Microcalcifications were modelled as small spheres having a composition of calcium carbonate. The results show that with a mean glandular dose equivalent to that typically used in two-view screening mammography, CT mammography with a flat-panel detector is capable of providing images where most microcalcifications are detectable. A receiver operating characteristic (ROC) study was conducted by five physicist observers viewing simulated CT mammography reconstructions. The results suggest that the microcalcification with its diameter equal to or greater than 0.175 mm can be detected with an average area under the ROC curve (AUC) greater than 0.95 using 0.1 or 0.2 mm pixelized detectors. The results also indicate that the optimal pixel size of the detector is around 0.2 mm for microcalcification detection, based on the trade-off between detectability of microcalcifications and the time required for data acquisition and reconstruction.