Colonic fermentation from lactulose inhibits lipolysis in overweight subjects
Colonic fermentation from lactulose inhibits lipolysis in overweight subjects
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DOI：
10.1152/ajpendo.00430.2004
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发表时间：
2005-10-01
影响因子：
5.1
通讯作者：
Krempf, M
中科院分区：
文献类型：
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作者：
Ferchaud-Roucher, V;Pouteau, E;Krempf, M
预防胰岛素抵抗的策略之一是减少循环游离脂肪酸（FFA）。本研究的目的是评估口服乳果糖负荷对超重受试者脂肪酸代谢的影响。8名超重受试者接受了预充的[1-C-13]醋酸盐和[1，1，2，3，3-H-2（5）]甘油持续静脉输注9 h。示踪剂输注3小时后，患者摄入30 g乳果糖或盐水溶液。每20分钟采集一次动脉化血液样本。醋酸盐的基础血浆浓度在口服治疗前和治疗间以及甘油和FFA浓度相似。血浆醋酸盐周转率为11.4 +/- 2.4 vs. 10.7 +/- 1.4 μ mol中心点kg（-1）中心点min（-1）[不显著（NS）]，血浆甘油周转率为3.8 +/- 0.4 vs. 4.8 +/- 1.9 μ mol中心点kg（-1）中心点min（-1）（NS）。乳果糖摄入后，乙酸盐浓度增加两倍，然后下降到基线。乳果糖处理后，乙酸周转率增加到15.5 +/- 2.2 μ mol中心点kg（-1）中心点min（-1），而盐水处理后无变化（10.3 +/- 2.2 μ mol中心点kg（-1）中心点min（-1），P
One of the strategies to prevent insulin resistance is to reduce circulating free fatty acids (FFA). The aim of this study is to assess the effect of an oral lactulose load on fatty acid metabolism in overweight subjects. Eight overweight subjects received a primed constant intravenous infusion of [1-C-13] acetate and of [1,1,2,3,3-H-2(5)] glycerol for 9 h. After 3 h of tracer infusion, patients ingested 30 g lactulose, or saline solution. Arterialized blood samples were collected every 20 min. Basal plasma concentrations of acetate were similar before and between oral treatments as well as glycerol and FFA concentrations. Plasma acetate turnover was 11.4 +/- 2.4 vs. 10.7 +/- 1.4 mu mol center dot kg(-1) center dot min(-1) [not significant (NS)], and plasma glycerol turnover was 3.8 +/- 0.4 vs. 4.8 +/- 1.9 mu mol center dot kg(-1) center dot min(-1) (NS). After lactulose ingestion, acetate concentration increased twofold and then decreased to baseline. Acetate turnover rate increased to 15.5 +/- 2.2 mu mol center dot kg(-1) center dot min(-1) after lactulose treatment, whereas it was unchanged after saline treatment (10.3 +/- 2.2 mu mol center dot kg(-1) center dot min(-1), P