Gastrointestinal distress as a potential mediator between stress and periodontal inflammation.
Gastrointestinal distress as a potential mediator between stress and periodontal inflammation.
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胃肠道不适是压力和牙周炎症之间的潜在中介。
DOI：
10.1111/cdoe.12889
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发表时间：
2023
影响因子：
2.3
通讯作者：
McNeil,DanielW
中科院分区：
文献类型：
--
作者：
Wright,CaseyD;Heaton,Brenda;Garcia,RaulI;Leonard,MaureenM;Fasano,Alessio;McNeil,DanielW
目的牙周病的病因是多因素的，其中包括生物、心理和社会因素，包括心理压力。胃肠道不适和生物失调与几种慢性炎症性疾病有关，但很少有关于口腔炎症的研究。鉴于胃肠道痛苦对肠外炎症的影响，本研究旨在评估这种痛苦作为心理应激和牙周病之间的中介的潜在作用。方法利用Amazon Machine Turk生成的828名美国成年人的横断面全国样本，我们评估了一系列有效的心理社会问卷收集的数据，这些问卷涉及当前胃肠道痛苦和牙周病的压力、肠源性焦虑和牙周病，包括针对生理和功能因素的牙周病子量表。在控制协变量的同时，使用结构方程模型来确定总的、直接的和间接的影响。结果心理压力与胃肠道不适(？= .34)和自我报告的牙周病(？= .43)相关。胃肠道不适也与自我报告的牙周病有关(？= .10)。胃肠道不适同样在心理应激与牙周病之间起中介作用(？= .03，p= .015)。鉴于牙周病的多因素性质(S)，在牙周自评量表的子量表上也得到了类似的结果。结论心理应激与牙周病的总体报告以及更具体的生理和功能成分之间存在关联。此外，这项研究还提供了初步数据，支持胃肠道不适在连接肠道-大脑和肠道-牙床通路中所起的潜在机制作用。
ObjectivesPeriodontal disease is multifactorial in its aetiology, which encompasses biopsychosocial contributors, including psychological stress. Gastrointestinal distress and dysbiosis have been associated with several chronic inflammatory diseases yet have rarely been investigated with respect to oral inflammation. Given the implications of gastrointestinal distress on extraintestinal inflammation, this study aimed to evaluate the potential role of such distress as a mediator between psychological stress and periodontal disease.MethodsUtilizing a cross‐sectional, nationwide sample of 828 adults in the USA generated via Amazon Mechanical Turk, we evaluated data collected from a series of validated self‐report psychosocial questionnaires on stress, gut‐specific anxiety around current gastrointestinal distress and periodontal disease, including periodontal disease subscales targeted at physiological and functional factors. Structural equation modelling was used to determine total, direct and indirect effects, while controlling for covariates.ResultsPsychological stress was associated with gastrointestinal distress (ß= .34) and self‐reported periodontal disease (ß= .43). Gastrointestinal distress also was associated with self‐reported periodontal disease (ß= .10). Gastrointestinal distress likewise mediated the relation between psychological stress and periodontal disease (ß= .03,p= .015). Given the multifactorial nature of periodontal disease(s), similar results were demonstrated using the subscales of the periodontal self‐report measure.ConclusionsAssociations exist between psychological stress and overall reports of periodontal disease as well as more specific physiological and functional components. Additionally, this study provided preliminary data supporting the potential mechanistic role that gastrointestinal distress plays in connecting the gut–brain and the gut–gum pathways.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
DOI：
10.1152/ajpgi.00230.2018
发表时间：
2018-11-01
影响因子：
4.5
作者：
Bajaj, Jasmohan S.;Matin, Payam;Sahingur, Sinem E.
通讯作者：
Sahingur, Sinem E.
理解心理过程在疾病发展、维持和治疗中的作用的框架：3P 疾病模型
影响因子：
3.8
作者：
C. Wright;Alaina G. Tiani;A. Billingsley;Shari A. Steinman;K. Larkin;D. McNeil
通讯作者：
D. McNeil
影响因子：
4.3
作者：
Genco, RJ;Ho, AW;Tedesco, LA
通讯作者：
Tedesco, LA
DOI：
10.1902/annals.1998.3.1.288
发表时间：
1998-07-01
期刊：
Annals of periodontology
影响因子：
--
作者：
Genco, R J;Ho, A W;Tedesco, L A
通讯作者：
Tedesco, L A