Decision formation in parietal cortex transcends a fixed frame of reference.
Decision formation in parietal cortex transcends a fixed frame of reference.
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DOI：
10.1016/j.neuron.2022.07.019
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发表时间：
2022-10-05
期刊：
影响因子：
16.2
通讯作者：
Shadlen, Michael N.
中科院分区：
文献类型：
--
作者：
So, NaYoung;Shadlen, Michael N.
当一个决定与一个特定的动作联系在一起时，比如眼球运动到一个选择目标时，外侧顶叶内皮层的神经元就代表了这个决定的形成。然而，这些神经元应该无法代表一个决定，这个决定会在破坏这种联系的行为中发生。我们通过同时记录两只恒河猴的许多神经元来研究这种限制。虽然干预行动破坏了单个神经元的表示，但集成通过将信息从当前活跃的神经元传递到行动后将变得活跃的神经元来实现决策过程的连续性。通过这种方式，演化决策的表示可以跨动作进行泛化，并超越指定神经响应字段的参考框架。这一发现扩展了先前对感受野重新映射的观察，认为这支持了眼球运动中感知的稳定性，也支持了思维过程的连续性，例如决策。LIP区的神经元在以眼为中心的参照系中代表意图。因此，当在注视方向改变之前和之后获得证据时，它们无法代表决策。So和Shadlen表明，决策的连续性是通过神经元之间的信息传递而产生的。
Neurons in the lateral intraparietal cortex represent the formation of a decision when it is linked to a specific action, such as an eye movement to a choice target. However, these neurons should be unable to represent a decision that transpires across actions that would disrupt this linkage. We investigated this limitation by simultaneously recording many neurons from two rhesus monkeys. Although intervening actions disrupt the representation by single neurons, the ensemble achieves continuity of the decision process by passing information from currently active neurons to neurons that will become active after the action. In this way, the representation of an evolving decision can be generalized across actions and transcends the frame of reference that specifies the neural response fields. The finding extends previous observations of receptive field remapping, thought to support the stability of perception across eye movements, to the continuity of a thought process, such as a decision. Neurons in area LIP represent intention in an oculocentric frame of reference. They are therefore unable to represent a decision when evidence is acquired before and after a change of gaze direction. So and Shadlen show that continuity of a decision arises via transfer of information from neuron to neuron.
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DOI：
10.1098/rstb.2007.2054
发表时间：
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影响因子：
6.3
作者：
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影响因子：
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