Modified olfactory training in patients with postinfectious olfactory loss
Modified olfactory training in patients with postinfectious olfactory loss
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DOI：
10.1002/lary.25245
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发表时间：
2015-08-01
期刊：
影响因子：
2.6
通讯作者：
Hummel, Thomas
中科院分区：
文献类型：
--
作者：
Altundag, Aytug;Cayonu, Melih;Hummel, Thomas
目标/假设有嗅觉功能障碍的患者可以从反复接触气味中受益，即所谓的嗅觉训练（OT）。这并不意味着偶尔闻一闻，而是每天两次有组织地嗅一组特定的气味，持续 4 个月或更长时间。在这项前瞻性研究中，我们调查了是否可以通过使用更多气味和延长训练时间来提高 OT 的效果。研究设计和方法本研究显示了感染后嗅觉功能障碍患者使用 4 种或 12 种气味 36 周后的 OT 结果。共有 85 名受试者参与（平均年龄 45.610.5 岁，范围 24-68 岁）。分为三组：1）在改良嗅觉训练（MOT）组中，患者依次使用三组四种不同的气味。 2）经典气味训练（COT）组的参与者使用四种气味。 3）对照组的参与者没有进行OT。所有组的参与者的年龄和性别分布都进行了匹配。结果COT 和 MOT 组的参与者在气味辨别和气味识别方面都比对照组获得了更好的分数。与在整个研究中使用相同的四种气味相比，在第 12 周和第 24 周后继续使用四种不同的气味进行 OT 在气味辨别和气味识别分数方面产生了更好的结果。结论这项研究证实了 OT 的有效性。增加 OT 的持续时间和改变气味可以提高该疗法的成功率。证据水平 2b。喉镜，125：1763-1766，2015
Objectives/HypothesisPatients with olfactory dysfunction benefit from repeated exposure to odors, so-called olfactory training (OT). This does not mean occasional smelling but the structured sniffing of a defined set of odors, twice daily, for a period of 4 months or longer. In this prospective study, we investigated whether the effect of OT might increase through the use of more odors and extension of the training period.Study Design and MethodsThis study shows OT results when performed with four or 12 odors for 36 weeks in patients with postinfectious olfactory dysfunction. A total of 85 subjects participated (mean age 45.610.5 years, range 24-68 years). Three groups were formed: 1) In the modified olfactory training (MOT) group, patients used three sets of four different odors sequentially. 2) Participants in the classical odor training (COT) group used four odors. 3) Participants in the control group did not perform OT. All groups were matched for age and sex distribution of participants.ResultsBoth participants in the COT and MOT groups reached better scores than controls in terms of odor discrimination and odor identification. Continuing OT with four different odors after the 12th and 24th weeks produced better results in terms of odor discrimination and odor identification scores as compared to using the same four odors throughout the entire study.ConclusionThis study confirmed the effectiveness of OT. Increasing the duration of OT and changing the odors enhances the success rate of this therapy.Level of Evidence2b. Laryngoscope, 125:1763-1766, 2015