Xanthohumol does not affect the composition of rat intestinal microbiota
Xanthohumol does not affect the composition of rat intestinal microbiota
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DOI：
10.1002/mnfr.200500048
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发表时间：
2005-09-01
影响因子：
5.2
通讯作者：
Braune, A
中科院分区：
文献类型：
--
作者：
Hanske, L;Hussong, R;Braune, A
黄腐酚（XN）是一种戊基化查尔酮，被认为对人体健康有有益的影响，包括抗菌活性。为了弄清暴露于XN是否对肠道微生物群的组成有影响，每天给大鼠100 mg XN/kg体重，持续4周。采用PCR-DGGE分析了粪便微生物群落的多样性。虽然在大鼠粪便中检测到完整的XN，浓度高达2.3 mg/g粪便干重，但没有观察到PCR-DGGE模式对这种类黄酮的反应发生重大变化。xn处理大鼠的相似指数从70下降到62%，未处理大鼠的相似指数从71下降到63%。因此，在XN应用过程中观察到的大鼠粪便微生物群的变化很可能是由于个体差异造成的。但在XN处理期间，粪便含水量显著增加。
Xanthohumol (XN), a prenylated chalcone, has been proposed to have beneficial effects on human health, including antimicrobial activity. To clarify whether the exposure to XN has an impact on the composition of the intestinal microbiota, 100 mg XN/kg body weight was given daily to rats for 4 wk. Diversity of the fecal microbial community was analyzed using PCR-DGGE. Although intact XN was detected in the feces of the rats at a concentration of up to 2.3 mg/g fecal dry weight, major shifts in the PCR-DGGE patterns in response to this flavonoid were not observed. The similarity index decreased slightly from 70 to 62% for the XN-treated rats and from 71 to 63% for the untreated animals. Thus, changes in the rat fecal microbiota observed in the course of the XN application are most likely due to intraindividual variability. However, the water content of the feces increased significantly during the XN treatment period.