MetaHIT: The European Union Project on Metagenomics of the Human Intestinal Tract
MetaHIT: The European Union Project on Metagenomics of the Human Intestinal Tract
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DOI：
10.1007/978-1-4419-7089-3_15
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Ehrlich, S. Dusko
中科院分区：
文献类型：
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作者：
Ehrlich, S. Dusko
MetaHIT(http://www.metahit.eu))的首要目标是创建肠道微生物基因目录，从而为肠道微生物群落的特征奠定基础。接下来，它的目标是探索微生物基因和人类表型之间的联系。为此，它一方面开发了分子工具，用于描绘任何个人拥有的肠道微生物基因，另一方面开发了一种生物信息学资源，用于组织和解释不同的信息，包括测序数据和临床元数据。此外，MetaHIT开发了检测和分析微生物与人类宿主功能相互作用的方法，重点关注目标基因在微生物细胞中的作用以及基因产品对人类宿主的影响。MetaHIT针对两种病理，肥胖和炎症性肠道疾病(克罗恩病和溃疡性结肠炎)。这些研究涉及(I)健康和患病个人的横向比较；(Ii)对临床缓解期患者的纵向跟踪；(Iii)与肠道微生物群落稳定有关的营养干预；以及(Iv)比较患者对药物治疗的反应或无效。
MetaHIT (http://www.metahit.eu) has as a first objective the creation of a catalog of the microbial genes from our intestinal tract, thus laying foundations for characterization of the gut microbial communities. Next, it aims to explore associations between microbial genes and human phenotypes. For that, it develops, on the one hand, molecular tools for profiling of the intestinal microbial genes that are harbored by any individual, and on the other, a bio-informatics resource to organize and interpret heterogeneous information, including sequencing data and clinical metadata. Moreover, MetaHIT develops approaches to detect and analyze functional interactions of microbes and the human host, focusing on the role of target genes in the microbial cell and the effect of gene products on the human host. MetaHIT targets two pathologies, obesity and inflammatory bowel diseases (Crohn’s disease and ulcerative colitis). The studies involve (i) cross-sectional comparisons of healthy and sick individuals; (ii) longitudinal follow-up of patients in clinical remission; (iii) nutritional intervention related to the stability of gut microbial community; and (iv) comparison of patients responding or not to a drug treatment.