GIANT-CELL TUMOR OF BONE - A UNIQUE PARADIGM OF STROMAL-HEMATOPOIETIC CELLULAR INTERACTIONS
GIANT-CELL TUMOR OF BONE - A UNIQUE PARADIGM OF STROMAL-HEMATOPOIETIC CELLULAR INTERACTIONS
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DOI：
10.1002/jcb.240550305
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发表时间：
1994-07-01
影响因子：
4
通讯作者：
EINHORN, TA
中科院分区：
文献类型：
--
作者：
ROBINSON, D;EINHORN, TA
骨巨细胞瘤是一种进行性的、潜在的恶性过程，通过其破骨细胞补体破坏骨骼组织。作为一种生物实体，它为破骨细胞的骨吸收提供了一种独特的自然模型，破骨细胞的招募和发育受成纤维细胞样细胞的肿瘤群体的控制。了解这种肿瘤的发病机制可以为了解正常和病变骨骼中成骨细胞-破骨细胞相互作用的机制提供新的见解。最近的研究表明，巨细胞瘤中的间质细胞是唯一增殖的细胞亚群，而巨细胞本身是非增殖性和反应性的。这些基质细胞表达几个与成骨细胞表型相关的基因，在有限的程度上合成与骨相关的某些基质蛋白，并表达几个可能参与破骨细胞募集的因子。在培养中，巨细胞瘤相关基质细胞通过分泌因子或细胞-细胞接触促进单核细胞的融合和成骨细胞的增殖。因此，骨巨细胞瘤是一个自给自足的生物系统，在这个系统中，基质和造血系的细胞以类似于正常骨骼重塑的方式相互作用。然而，基质成分的肿瘤性驱使造血祖细胞进行融合，产生侵袭性的骨吸收，并导致广泛的骨骼破坏。对这一系统的各个组成部分的研究可能会为更好地了解成骨细胞-破骨细胞的相互作用提供新的研究方向。(C)1994年Wiley-Liss，Inc.
Giant cell tumor of bone is a progressive, potentially malignant process which destroys skeletal tissue by virtue of its osteoclast complement. As a biological entity it provides a unique natural model of bone resorption by osteoclasts whose recruitment and development is controlled by a neoplastic population of fibroblast-like cells. Understanding of the etiopathogenesis of this tumor could provide new insights into the mechanisms underlying osteoblast-osteoclast interactions in normal and diseased bone. Recent studies have shown that the stromal cell component in giant cell tumors is the only proliferating subpopulation of cells, and the giant cells themselves are nonproliferative and reactive. These stromal cells express several genes associated with the osteoblastic phenotype, synthesize, to a limited degree, certain matrix proteins associated with bone, and express several factors which are presumably involved in the recruitment of osteoclasts. In culture, giant cell tumor-associated stromal cells promote the fusion of monocytes and the proliferation of osteoblasts either by the secretion of factors or cell-cell contact. Hence, giant cell tumor of bone is a self-contained biosystem in which cells of both the stromal and hematopoietic lineages interact in a fashion similar to that observed in normal skeletal remodeling. The neoplastic nature of the stromal component, however, drives the hematopoietic precursors to undergo fusion, produces aggressive bone resorption, and results in extensive skeletal destruction. Examination of the various components of this system could lead to new directions for investigations aimed at a better understanding of osteoblast-osteoclast interactions. (C) 1994 Wiley-Liss, inc.