Minireview: Metabolic control of the reproductive physiology: insights from genetic mouse models.
Minireview: Metabolic control of the reproductive physiology: insights from genetic mouse models.
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DOI：
10.1016/j.yhbeh.2014.04.007
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发表时间：
2014-06
影响因子：
3.5
通讯作者：
Elias, Carol F.
中科院分区：
文献类型：
--
作者：
Bellefontaine, Nicole;Elias, Carol F.
在过去的二十年里，特别是在过去的5-7年里，在对生殖生理学代谢控制的理解方面取得了巨大的进步。这在很大程度上是由于基因靶向工具和分子作图技术的进步和完善。然而，尽管通过使用新的小鼠模型出现了令人兴奋且经常发人深省的数据，但在这一过程中，对基因靶向策略的严重依赖已成为根本，因此在解释结果时必须谨慎。这篇小综述文章将探讨使用遗传操作（如病毒载体递送和Cre/loxP系统的使用）产生新的小鼠模型，以研究循环代谢激素在生殖生理协调中的作用。此外，我们还将强调在当前的范例中使用遗传操作的一些陷阱。然而，它已经变得很清楚，代谢线索采用集成和可塑性的神经回路，以调节神经内分泌生殖轴，尽管最近的进展仍有待阐明有关此电路。
Over the past two decades, and in particular over the past 5-7 years, there has been a tremendous advancement in the understanding of the metabolic control of reproductive physiology. This has been in large part due to the advancement and refinement of gene targeting tools and techniques for molecular mapping. Yet despite the emergence of exciting and often times thought-provoking data through the use of new mouse models, the heavy reliance on gene targeting strategies has become fundamental in this process and thus caution must be exercised when interpreting results. This minireview article will explore the generation of new mouse models using genetic manipulation, such as viral vector delivery and the use of the Cre/loxP system, to investigate the role of circulating metabolic hormones in the coordination of reproductive physiology. In addition, we will also highlight some of the pitfalls in the use of genetic manipulation in the current paradigms. However, it has become clear that metabolic cues employ integrated and plastic neural circuits in order to modulate the neuroendocrine reproductive axis, and despite recent advances much remains to be elucidated about this circuitry.
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影响因子：
82.9
作者：
Altarejos, Judith Y.;Goebel, Naomi;Conkright, Michael D.;Inotiel, Hiroshi;Xie, Jianxin;Arias, Carlos M.;Sawchenko, Paul E.;Montminy, Marc
通讯作者：
Montminy, Marc
DOI：
10.1073/pnas.1834399100
发表时间：
2003-09-16
影响因子：
11.1
作者：
de Roux, N;Genin, E;Milgrom, E
通讯作者：
Milgrom, E
DOI：
10.1038/oby.2005.7
发表时间：
2005-01-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Carvalheira, JBC;Torsoni, MA;Saad, MJA
通讯作者：
Saad, MJA
影响因子：
56.9
作者：
Bouret, SG;Draper, SJ;Simerly, RB
通讯作者：
Simerly, RB
影响因子：
15.9
作者：
Bjornholm, Marie;Munzberg, Heike;Myers, Martin G., Jr.
通讯作者：
Myers, Martin G., Jr.