EPIDEMIOLOGY OF OCULAR HERPES-SIMPLEX - NATURAL-HISTORY IN ROCHESTER, MINN, 1950 THROUGH 1982
EPIDEMIOLOGY OF OCULAR HERPES-SIMPLEX - NATURAL-HISTORY IN ROCHESTER, MINN, 1950 THROUGH 1982
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DOI：
10.1001/archopht.1989.01070020226030
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发表时间：
1989-08-01
影响因子：
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通讯作者：
LIESEGANG, TJ
中科院分区：
文献类型：
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作者：
LIESEGANG, TJ
在1950年至1982年期间，明尼苏达州罗切斯特的151名居民中有294例眼部单纯疱疹病毒感染。首次发病后1年、2年和20年的复发率分别为9.6%、22.9%和63.2%。反复发作后复发率似乎上升。18例患者（11.9%）在相同和/或不同的发作期出现双眼单纯疱疹。五分之一的患者仅累及眼睑，而三分之一的患者仅累及浅层角膜。深部角膜疾病或葡萄膜炎相对少见。早期的治疗方法多种多样，但严重的并发症并不常见。90%的眼睛保持20/40或更好的视力。以活动性疾病和医生就诊天数衡量，经济影响是巨大的。
In the period 1950 through 1982, there were 294 episodes of ocular herpes simplex virus infection in 151 residents of Rochester, Minn. Recurrence rates assessed by life-table methods after the first episode were 9.6% at 1 year, 22.9% at 2 years, and 63.2% at 20 years. Recurrence rates appeared to rise following repeated episodes. Ocular herpes simplex affecting both eyes at the same and/or different episodes was seen in 18 patients (11.9%). One fifth of patients had lid involvement alone, while a third had solely superficial corneal involvement. Deep corneal disease or uveitis was relatively uncommon. Thereapy during the early period was varied, but significant complications were uncommon. Ninety percent of the eyes maintained visual acuity of 20/40 or better. The economic impact, measured in terms of days of active disease and physician visits, was substantial.