Monaural and binaural response properties of single neurons in the rat's dorsal nucleus of the lateral lemniscus
Monaural and binaural response properties of single neurons in the rat's dorsal nucleus of the lateral lemniscus
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DOI：
10.1016/s0378-5955(98)00082-3
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发表时间：
1998-08-01
期刊：
影响因子：
2.8
通讯作者：
Kidd, SA
中科院分区：
文献类型：
--
作者：
Kelly, JB;Buckthought, AD;Kidd, SA
在细胞外记录大鼠外侧丘系背核(DNLL)单个神经元的微电极，并测定单耳和双耳刺激的反应特征。绝大多数DNLL神经元被狭隘地调谐到声音频率，它们对对侧音调脉冲的时间反应可分为三大类：开始(57%)、持续(21%)或开始-暂停-持续(22%)。大多数DNLL神经元在一次点击中向对侧耳发出多个动作电位。大部分DNLL神经元(77%)表现为对侧声压级升高的单音脉冲诱发的棘波数目单调增加，其余细胞呈弱非单调。DNLL内神经元的特征频率分布未见明显的强直模式。大多数DNLL神经元表现出兴奋/抑制(74%)或兴奋/兴奋(9%)双耳反应模式。其余的细胞(17%)是单耳的，完全由刺激对侧耳驱动。DNLL中的双耳神经元对耳间强度和耳间时间差都很敏感，这分别由双耳短脉冲和短声的呈现决定。根据单耳和双耳反应特征，DNLL神经元的反应可与周围区域包括鞍区、丘脑旁带和外侧丘系中间核的反应区分开来。(C)1998 Elsevier Science B.V.保留所有权利。
Extracellular recordings were made with microelectrodes from single neurons in the rat's dorsal nucleus of the lateral lemniscus (DNLL) and response characteristics were determined for monaural and binaural acoustic stimulation. The vast majority of DNLL neurons were narrowly tuned to sound frequency and their temporal responses to contralateral tone pulses fell into one of three broad categories: onset (57%), sustained (21%) or onset-pause-sustained (22%). Most DNLL neurons fired multiple action potentials to a single click delivered to the contralateral ear. The majority (77%) of DNLL neurons showed a monotonic increase in the number of spikes elicited by contralateral tone pulses of increasing sound pressure level; the remaining cells were weakly non-monotonic. No obvious tonotopic pattern was found in the distribution of characteristic frequency of neurons in DNLL. Most DNLL neurons exhibited either excitatory/inhibitory (74%) or excitatory/excitatory (9%) binaural response patterns. The remaining cells (17%) were monaural and driven exclusively by stimulation of the contralateral ear. The binaural neurons in DNLL were sensitive to both interaural intensity and interaural time differences as determined by presentation of dichotic tone bursts and clicks respectively. The responses of DNLL neurons could be distinguished on the basis of monaural and binaural response characteristics from those in surrounding areas including the sagulum, paralemniscal zone and the intermediate nucleus of the lateral lemniscus. (C) 1998 Elsevier Science B.V. All rights reserved.