New transformation tricks from a barnyard retrovirus: Implications for human lung cancer
New transformation tricks from a barnyard retrovirus: Implications for human lung cancer
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谷仓逆转录病毒的新转化技巧：对人类肺癌的影响
DOI：
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发表时间：
2001
影响因子：
11.1
通讯作者：
N. Rosenberg
中科院分区：
文献类型：
--
作者：
N. Rosenberg
致癌逆转录病毒的研究为我们目前对致癌分子机制的理解提供了很大的智力基础。蛋白酪氨酸激酶和RAS在生长刺激中的作用以及生长控制基因表达失调导致肿瘤发生的无数途径，这些都是深植于逆转录病毒学的概念。事实上，目前已知与人类癌症有关的50多个癌基因是在逆转录病毒模型中首次发现和研究的(1)。然而，只有一种逆转录病毒，人类T细胞淋巴营养病毒(HTLV)在人类中是致癌的，随着我们进入21世纪，逆转录病毒致癌模型似乎在很大程度上具有历史意义。然而，前田等人对Jaagsiekte绵羊逆转录病毒(JSRV)的分析。(2)和Rai等人。(3)在本期PNAS中的研究揭示了致癌逆转录病毒仍然持有可能与人类癌症直接相关的重要秘密。
对Jaagsiekte绵羊逆转录病毒的分析表明，致癌逆转录病毒仍然拥有可能与人类癌症直接相关的重要秘密。
Studies of oncogenic retroviruses provided much of the intellectual foundation for our current understanding of the molecular mechanisms of carcinogenesis. The now well-established role of protein tyrosine kinases and Ras in growth stimulation and the myriad ways by which dysregulated expression of growth control genes can lead to tumor development are concepts deeply rooted in retrovirology. Indeed, more than 50 oncogenes now known to be involved in human cancers were first discovered and studied in retroviral models (1). Nonetheless, only one retrovirus, human T cell lymphotrophic virus (HTLV), is oncogenic in humans, and, as we enter the 21st century, retroviral oncogenesis models may seem to be of largely historical interest. However, analyses of jaagsiekte sheep retrovirus (JSRV) by Maeda et al. (2) and Rai et al. (3) in this issue of PNAS reveal that oncogenic retroviruses still hold important secrets that may be directly relevant to human cancer.
Analyses of jaagsiekte sheep retrovirus reveal that oncogenic retroviruses still hold important secrets that may be directly relevant to human cancer.
绵羊和山羊呼吸系统逆转录病毒相关肿瘤。
DOI：
10.1016/s0749-0720(15)30364-9
发表时间：
1997
期刊：
The Veterinary clinics of North America. Food animal practice
影响因子：
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作者：
DeMartini,JC;York,DF
通讯作者：
York,DF
影响因子：
11.2
作者：
M. Lerman;J. Minna
通讯作者：
M. Lerman;J. Minna
影响因子：
5
作者：
Knobbe, CB;Trampe-Kieslich, A;Reifenberger, G
通讯作者：
Reifenberger, G