Independence of circadian timing from cell division in cyanobacteria
Independence of circadian timing from cell division in cyanobacteria
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DOI：
10.1128/jb.183.8.2439-2444.2001
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发表时间：
2001-04-01
影响因子：
3.2
通讯作者：
Johnson, CH
中科院分区：
文献类型：
--
作者：
Mori, T;Johnson, CH
在蓝细菌Synechococcus elongatus中，细胞分裂受生物钟的调节。生物钟基因kaiC的缺失，废除了基因表达和细胞分裂时间的节律。ftsZ基因的过表达阻止了细胞分裂，但没有阻止细胞生长，导致细胞生长为细丝而不分裂。不分裂的丝状细胞仍然表现出强大的基因表达的昼夜节律。这一结果表明，昼夜节律计时系统是独立的节奏细胞分裂，并与其他结果一起，表明蓝藻昼夜节律系统是稳定的，以及在广泛的细胞内条件下持续。
In the cyanobacterium Synechococcus elongatus, cell division is regulated by a circadian clock Deletion of the circadian clock gene, kaiC, abolishes rhythms of gene expression and cell division timing. Overexpression of the ftsZ gene halted cell division but not growth, causing cells to grow as filaments without dividing. The nondividing filamentous cells still exhibited robust circadian rhythms of gene expression. This result indicates that the circadian timing system is independent of rhythmic cell division and, together with other results, suggests that the cyanobacterial circadian system is stable and well sustained under a wide range of intracellular conditions.