ENDORPHINS ALTER ACQUISITION AND CONSOLIDATION OF AN INHIBITORY AVOIDANCE-RESPONSE IN RATS
ENDORPHINS ALTER ACQUISITION AND CONSOLIDATION OF AN INHIBITORY AVOIDANCE-RESPONSE IN RATS
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DOI：
10.1016/0304-3940(80)90194-9
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发表时间：
1980-01-01
影响因子：
2.5
通讯作者：
RIGTER, H
中科院分区：
文献类型：
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作者：
MARTINEZ, JL;RIGTER, H
1.0 μg/kg γ-内啡肽在1次抑制性回避任务训练前30分钟外周ig给药，72 h后测量保留率。训练后立即给予0.1 μg/kg β-内啡肽的更小剂量会产生潴留缺陷。这两种内啡肽的作用都是时间依赖性的，因为在训练前90分钟给予γ-内啡肽，在训练后90分钟给予β-内啡肽，对保持表现没有影响。训练后大剂量γ-内啡肽（0.1 ~ 10 μg/kg）和训练前大剂量β-内啡肽（0.1 ~ 10 μg/kg）均无影响。这些结果表明β-内啡肽和较小的β-促脂素序列（如γ-内啡肽）的行为作用是不同的。我们还发现，在训练前后给予0.1-100 μg/kg的α-内啡肽或met -脑啡肽对反应的保持没有影响。
Peripheral i.p. administration of 1.0 μg/kg γ-endorphin to rats, 30 min prior to training in a 1-trial inhibitory avoidance task, enhanced retention performance measured 72 h later. A much smaller dose of 0.1 μg/kg β-endorphin administered immediately following training produced a retention deficit. Both of these endorphin effects were time dependent, since γ-endorphin given 90 min prior to, and β-endorphin given 90 min after training produced no effect on retention performance. A wide dose range of either γ-endorphin (0.1–10 μg/kg) administered after training or β-endorphin (0.1–10 μg/kg) administered before training had no effect. These results suggest that the behavioral actions of β-endorphin and smaller β-lipotropin sequences such as γ-endorphin, are distinct. We also found that 0.1–100 μg/kg of either α-endorphin or Met-enkephalin given before or after training was without effect on retention of the response.