Single Neurons in Anterior Cingulate Cortex Signal the Need to Change Action During Performance of a Stop-change Task that Induces Response Competition
Single Neurons in Anterior Cingulate Cortex Signal the Need to Change Action During Performance of a Stop-change Task that Induces Response Competition
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DOI：
10.1093/cercor/bhy008
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发表时间：
2019-03-01
期刊：
影响因子：
3.7
通讯作者：
Roesch, Matthew R.
中科院分区：
文献类型：
--
作者：
Bryden, Daniel W.;Brockett, Adam T.;Roesch, Matthew R.
几项人类成像研究表明，当参与者收到相互竞争的输入时，前扣带回(ACC)高度活跃，这些信号可能对影响下游行动计划很重要。尽管来自几项神经成像研究的证据越来越多，但还没有研究在执行类似任务的啮齿动物中检验单个神经元水平上的ACC活性。为了填补这一空白，我们记录了大鼠在执行停变任务时ACC中的单个神经元。我们发现，在有竞争输入的试验(停止试验)中，发射频率与准确度和移动速度呈正相关，这表明当使用ACC时，大鼠往往会放慢速度，表现得更好。最后，当停止试验之前进行围棋试验时，发射最强，当大鼠在停止试验之后的试验中调整它们的行为时，发射减少。这些数据首次证明，当两种反应相互竞争时，当需要改变行为过程以获得奖励时，ACC中单个神经元的活动会增加。
Several human imaging studies have suggested that anterior cingulate cortex (ACC) is highly active when participants receive competing inputs, and that these signals may be important for influencing the downstream planning of actions. Despite increasing evidence from several neuroimaging studies, no study has examined ACC activity at the level of the single neuron in rodents performing similar tasks. To fill this gap, we recorded from single neurons in ACC while rats performed a stop-change task. We found higher firing on trials with competing inputs (STOP trials), and that firing rates were positively correlated with accuracy and movement speed, suggesting that when ACC was engaged, rats tended to slow down and perform better. Finally, firing was the strongest when STOP trials were preceded by GO trials and was reduced when rats adapted their behavior on trials subsequent to a STOP trial. These data provide the first evidence that activity of single neurons in ACC is elevated when 2 responses are in competition with each other when there is a need to change the course of action to obtain reward.