The neural basis of executive function in working memory: an fMRI study based on individual differences
The neural basis of executive function in working memory: an fMRI study based on individual differences
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DOI：
10.1016/j.neuroimage.2003.09.069
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发表时间：
2004-02-01
期刊：
影响因子：
5.7
通讯作者：
Shibasaki, H
中科院分区：
文献类型：
--
作者：
Osaka, N;Osaka, M;Shibasaki, H
使用功能磁共振成像，神经基板的执行系统进行了调查方面的差异，工作记忆容量。采用阅读广度测验和阅读条件来探讨被试的执行控制过程。两个主题组被选中：那些与大的工作记忆容量，标记高跨度主题（HSS）根据阅读跨度测试，和那些与小的工作记忆容量，标记低跨度主题（LSS）。与对照组相比，激活主要集中在前扣带皮层（ACC）、左额下回（IFG）、视觉联想皮层（VAC）和上级顶叶小叶（SPL）。对于两组来说，与阅读条件下相比，在阅读条件下，ACC和IFG的fMRI信号强度在阅读条件下增加。在ACC和IFG区域也发现了组间差异，特别是仅在HSS组中观察到信号强度显著增加，而在LSS组中未观察到信号强度显著增加。行为数据还表明，在HSS中的性能优于LSS。HSS组ACC与IFG信号变化的相关性高于LSS组，提示HSS组ACC与IFG之间的网络系统比LSS组更为活跃。这些结果表明，执行功能，即工作注意控制系统在HSS比LSS更活跃。此外，结果证实了我们的假设，有一个一般的神经基础的中央执行功能，在两个新的和以前的LST（听广度测试）任务，尽管不同的模态特定的缓冲区。(C)2003年爱思唯尔公司All rights reserved.
Using fMRI, neural substrates of the executive system were investigated with respect to differences in working memory capacity. To explore the executive control processes, reading span test (RST) and read conditions were performed. Two subject groups were selected: those with large working memory capacities, labeled high-span subjects (HSS) according to the reading span test, and those with small working memory capacities, labeled low-span subjects (LSS). Significant activation was found mainly in three regions in comparison with the control: anterior cingulate cortex (ACC), left inferior frontal gyros (IFG), visual association cortex (VAC) and superior parietal lobule (SPL). For both groups, the fMRI signal intensity increased in ACC and IFG during the RST condition compared to that under the read condition. A group difference was also found in the ACC and IFG region, specifically a significant increase in signal intensity was observed only for the HSS group but not for the LSS group. Behavioral data also showed that the performance was better in HSS than in LSS. Moreover, the cross correlation of signal change between ACC and IFG was higher in HSS than in LSS, indicating that the network system between ACC and IFG was more activated in HSS compared to that of LSS. These results suggest that executive function, that is, working attention controlling system is more active in HSS than in LSS. Moreover, the results confirmed our hypothesis that there is a general neural basis for the central executive function in both RST and previous LST (listening span test) tasks despite differences in modality-specific buffers. (C) 2003 Elsevier Inc. All rights reserved.