Responsiveness, inflammation, and effects of deep breaths on obstruction in mild asthma.
Responsiveness, inflammation, and effects of deep breaths on obstruction in mild asthma.
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DOI：
10.1152/jappl.1989.66.5.2298
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发表时间：
1989-05
影响因子：
3.3
通讯作者：
Lawrence B. Pliss;E. Ingenito;R. H. Ingram
中科院分区：
文献类型：
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作者：
Lawrence B. Pliss;E. Ingenito;R. H. Ingram
以支气管肺泡灌洗液(BAL)的细胞和生化特性为炎症指标，对16例特应性无症状轻度哮喘患者和6例正常人进行了深吸气(DI)后的气道管径改变、基线气道高反应性程度与周围气道炎症的关系。与正常对照组相比，哮喘组BAL中组胺、总蛋白、硫代多肽白三烯(SRS-A)和白三烯B4浓度显著升高；DI值在基线水平时，BAL的比导气率(SGaw)显著降低(SGaw百分比变化前为-10，SGaw百分比变化后为12，P<0.05)；BAL细胞总数和白细胞分类无显著差异。1)嗜酸性粒细胞百分比与气道高反应性程度；2)气道阻塞基线水平与高反应性程度；3)DI与嗜酸性粒细胞、总蛋白和组胺浓度的影响；4)基线强迫呼出量与S肺泡灌洗液中总蛋白和组胺浓度的相关性；以及5)各种介质的支气管肺泡灌洗液浓度之间的相互关系。这些数据支持这样的观点：1)轻度、稳定的哮喘患者对DI的反应代表着炎症引起的外周阻塞的生理指标，2)这种炎症与几种已知的呼吸道炎症和高反应性介质的增加有关。
Using cellular and biochemical characteristics of bronchoalveolar lavage (BAL) liquid as an index of inflammation, we examined the relationships between change of airway caliber after a deep inhalation (DI), degree of base-line airway hyperresponsiveness, and peripheral airway inflammation in a group of 16 atopic asymptomatic mild asthmatics and 6 normal subjects. Compared with normal subjects, asthmatics demonstrated 1) significantly higher BAL concentrations of histamine, total protein, the sulfidopeptide leukotrienes (SRS-A), and leukotiene B4; 2) a decrease in specific airway conductance (sGaw) with a DI at base line vs. an increase in normal subjects (before vs. after percent change in sGaw, -10 vs. 12, P less than 0.05); and 3) no significant difference in BAL total cell count or leukocyte differential. Significant correlations were demonstrated between 1) percent of BAL eosinophils vs. degree of airway hyperresponsiveness; 2) base-line level of airway obstruction vs. degree of hyperresponsiveness; 3) effects of a DI vs. BAL concentrations of eosinophils, total protein, and histamine; 4) base-line forced expired volume in 1 s vs. BAL concentrations of total protein and histamine; and 5) BAL concentrations of the various mediators with each other. These data support the notion that 1) the response to a DI in mild, stable asthmatics represents a physiological indicator of peripheral obstruction because of inflammation and 2) this inflammation is associated with increases in several known mediators of airway inflammation and hyperreactivity.