Longitudinal changes in cortical glucose hypometabolism in children with intractable epilepsy
Longitudinal changes in cortical glucose hypometabolism in children with intractable epilepsy
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DOI：
10.1177/08830738060210011101
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发表时间：
2006-01-01
影响因子：
1.9
通讯作者：
Chugani, Harry T.
中科院分区：
文献类型：
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作者：
Benedek, Krisztina;Juhasz, Csaba;Chugani, Harry T.
在部分性癫痫儿童中，越来越多的证据表明，并非所有在正电子发射断层扫描（PET）上显示葡萄糖代谢低下的皮质区域都代表致癫痫皮质，但某些代谢低下的区域可能是反复癫痫发作的结果。然而，大多数支持性数据来自横断面成像研究。为了评估皮质葡萄糖代谢低下的纵向变化，我们比较了15名患有难治性非病灶性部分性癫痫的儿童的两次连续[F-18]氟脱氧葡萄糖（FDG）PET扫描，间隔7至44个月。脑电图证实的癫痫灶一侧的代谢低下皮质的程度及其在两次PET扫描之间的变化进行了测量，并与临床癫痫发作变量相关。两次PET扫描之间癫痫发作频率的变化与皮质葡萄糖低代谢程度的变化呈正相关（r =.8，P
In children with partial epilepsy, there is increasing evidence to suggest that not all cortical regions showing glucose hypometabolism on positron emission tomography (PET) represent epileptogenic cortex but that some hypometabolic areas might be the result of repeated seizures. Most of the supportive data, however, have come from cross-sectional imaging studies. To evaluate longitudinal changes in cortical glucose hypometabolism, we compared two sequential [F-18]fluorodeoxyglucose (FDG) PET scans performed 7 to 44 months apart in 15 children with intractable nonlesional partial epilepsy. The extent of hypometabolic cortex on the side of the electroencephalography-verified epileptic focus and its changes between the two PET scans were measured and correlated to clinical seizure variables. The change in seizure frequency between the two PET scans correlated positively with the change in the extent of cortical glucose hypometabolism (r =.8, P