In vitro models for investigation of the effects of acute mechanical injury on cartilage.
In vitro models for investigation of the effects of acute mechanical injury on cartilage.
复制标题
用于研究急性机械损伤对软骨影响的体外模型。
DOI：
10.1097/00003086-200110001-00007
复制
发表时间：
2001
影响因子：
4.2
通讯作者：
Grodzinsky,AJ
中科院分区：
文献类型：
--
作者：
Patwari,P;Fay,J;Cook,MN;Badger,AM;Kerin,AJ;Lark,MW;Grodzinsky,AJ
已知关节创伤性损伤会增加继发性骨关节炎的风险，但尚不清楚这一过程是如何发生的。这种可导致骨关节炎风险增加的离散事件的存在激发了开发创伤性关节损伤体外模型的兴趣。目前的作者回顾了最近从这些模型系统中获得的一些关于骨关节炎发病机制的见解，包括机械损伤期间软骨细胞初始不可逆损伤的证据，凋亡软骨细胞死亡的发生，并试图确定创伤对软骨细胞代谢反应的影响。结果也从作者的正在进行的研究中创伤性机械负荷引起的降解途径，软骨细胞在压缩过程中受到影响的机制，以及关节囊对创伤后软骨降解的可能贡献。
Traumatic injury to a joint is known to increase the risk for the development of secondary osteoarthritis, but it is unclear how this process occurs. The existence of such a discrete event that can lead to an increased risk of osteoarthritis has spurred interest in developing in vitro models of traumatic joint injury. The current authors review some of the recent insights gained from these model systems into the pathogenesis of osteoarthritis, including the evidence for an initial, irreversible insult to chondrocytes during mechanical injury, the occurrence of apoptotic chondrocyte death, and attempts to identify the effects of trauma on chondrocyte metabolic response. Results also are presented from the authors' ongoing studies of the degradative pathways initiated by traumatic mechanical loads, the mechanism by which chondrocytes are affected during compression, and possible contributions of the joint capsule to posttraumatic cartilage degradation.