Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease
Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease
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DOI：
10.1080/10715760500233113
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发表时间：
2005-10-01
影响因子：
3.3
通讯作者：
Dexter, DT
中科院分区：
文献类型：
--
作者：
Zbarsky, V;Datla, KP;Dexter, DT
虽然帕金森病（PD）中多巴胺能细胞死亡的原因仍然未知，但氧化应激已被强烈牵连。由于其对抗氧化应激的能力，饮食来源的酚类化合物继续被认为是长期用于PD的潜在药物。本研究旨在探讨天然酚类化合物姜黄素、柚皮素、槲皮素、非瑟酮对6-OHDA帕金森病模型的神经保护作用。将6-OHDA单侧输注到内侧前脑束中导致黑质（SN）中酪氨酸羟化酶（TH）阳性细胞的显著损失以及溶媒处理动物纹状体中多巴胺（DA）含量的降低。用姜黄素或柚皮素预处理的大鼠显示出对纹状体中SN和DA水平的TH阳性细胞数量的明显保护。然而，无论是预处理槲皮素或非瑟酮TH阳性细胞或DA水平有任何影响。姜黄素和柚皮素在PD的6-OHDA模型中表现出神经保护的能力可能与其抗氧化能力和渗透到大脑中的能力有关。
Although the cause of dopaminergic cell death in Parkinson's disease (PD) remains unknown, oxidative stress has been strongly implicated. Because of their ability to combat oxidative stress, diet derived phenolic compounds continue to be considered as potential agents for long-term use in PD. This study was aimed at investigating whether the natural phenolic compounds curcumin, naringenin, quercetin, fisetin can be neuroprotective in the 6-OHDA model of PD. Unilateral infusion of 6-OHDA into the medial forebrain bundle produced a significant loss of tyrosine hydroxylase (TH)-positive cells in the substantia nigra (SN) as well as a decreased of dopamine (DA) content in the striata in the vehicle-treated animals. Rats pretreated with curcumin or naringenin showed a clear protection of the number of TH-positive cells in the SN and DA levels in the striata. However, neither pretreatment with quercetin nor fisetin had any effects on TH-positive cells or DA levels. The ability of curcumin and naringenin to exhibit neuroprotection in the 6-OHDA model of PD may be related to their antioxidant capabilities and their capability to penetrate into the brain.