Release of dexamethasone from PLGA nanoparticles entrapped into dextran/poly(vinyl alcohol) hydrogels
Release of dexamethasone from PLGA nanoparticles entrapped into dextran/poly(vinyl alcohol) hydrogels
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DOI：
10.1023/a:1014006800514
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发表时间：
2002-03-01
影响因子：
3.7
通讯作者：
Zhu, ZH
中科院分区：
文献类型：
--
作者：
Cascone, MG;Pot, PM;Zhu, ZH
采用物理交联法制备了聚乙烯醇(PVA)与葡聚糖共混物水凝胶，并将其作为包埋地塞米松的可生物降解纳米粒的载体，采用溶剂挥发法制备了可生物降解的聚乳酸-聚乙醇酸(PLGA)共聚物纳米粒，并用扫描电子显微镜对纳米粒的大小、形貌和表面特征进行了表征。研究了以PVA为载体的纳米粒的释药机理，并与游离纳米粒的释药机理进行了比较。考察了葡聚糖对地塞米松水凝胶体外释药的影响，结果表明PLGA纳米粒能够以扩散控制机制释放地塞米松。纳米粒子被包裹到水凝胶中对药物释放机制的影响很小。此外，与纯PVA水凝胶相比，葡聚糖/PVA水凝胶释放了更多的药物，并且随着水凝胶中葡聚糖含量的增加，药物释放量增加。(C)2002年克鲁沃学术出版社。
Hydrogels based on blends of poly(vinyl alcohol) (PVA) with dextran were prepared by a physical cross-linking procedure and used as matrices for the entrapment of biodegradable nanoparticles loaded with dexamethasone.The nanoparticles were prepared, by a solvent evaporation technique, using biodegradable copolymers of poly(lactic acid)-poly(glycolic acid) (PLGA).Size, morphology and surface characteristics of the nanoparticles were evaluated by scanning electron microscopy. The mechanism of drug release from the nanoparticles entrapped into the PVA-based matrices was studied and compared to that from free nanoparticles. The effect of dextran on the in vitro release profile of dexamethasone from the hydrogels was investigated.The obtained results indicate that PLGA nanoparticles are able to release dexamethasone following a diffusion-controlled mechanism. The entrapment of the nanoparticles into the hydrogels affects only slightly this mechanism of drug release.In addition, dextran/PVA hydrogels release a higher amount of drug with respect to pure PVA hydrogels and by increasing dextran content in the hydrogels, the amount of drug released increases. (C) 2002 Kluwer Academic Publishers.