Future research directions in acute lung injury - Summary of a National Heart, Lung, and Blood Institute working group
Future research directions in acute lung injury - Summary of a National Heart, Lung, and Blood Institute working group
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DOI：
10.1164/rccm.200208-966ws
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发表时间：
2003-04-01
影响因子：
24.7
通讯作者：
Harabin, AL
中科院分区：
文献类型：
--
作者：
Matthay, MA;Zimmerman, GA;Harabin, AL
急性肺损伤 (ALI) 及其更严重的形式急性呼吸窘迫综合征 (ARDS) 是由急性肺水肿和炎症引起的急性呼吸衰竭综合征。 ALI/ARDS 的发展与多种临床疾病相关，包括肺炎和误吸引起的直接肺损伤，以及创伤、脓毒症和其他疾病（如急性胰腺炎和药物过量）引起的间接肺损伤。尽管获奖死亡率在过去十年中有所下降，但仍然很高。尽管在治疗方面取得了两项重大进展，即治疗 ALI/ARDS 的低 V-T 通气和治疗严重脓毒症（ALI/ARDS 的主要原因）的活化蛋白 C，但仍需要开展更多研究来开发具体治疗方法并提高对这些综合征发病机制的了解。 NHLBI 召集了一个工作组，为未来的 ALI/ARDS 研究制定具体建议。通过使用不断发展的生物学、基因组和遗传学方法提高对疾病异质性的理解应该为 ALI 的发病机制提供重要的新见解。细胞和分子方法与动物和临床研究相结合，应该会在这种复杂疾病的检测和治疗方面取得进一步进展。
Acute lung injury (ALI) and its more severe form, the acute respiratory distress syndrome (ARDS), are syndromes of acute respiratory failure that result from acute pulmonary edema and inflammation. The development of ALI/ARDS is associated with several clinical disorders including direct pulmonary injury from pneumonia and aspiration as well as indirect pulmonary injury from trauma, sepsis, and other disorders such as acute pancreatitis and drug overdose. Although mortality from AWARDS has decreased in the last decade, it remains high. Despite two major advances in treatment, low V-T ventilation for ALI/ARDS and activated protein C for severe sepsis (the leading cause of ALI/ARDS), additional research is needed to develop specific treatments and improve understanding of the pathogenesis of these syndromes. The NHLBI convened a working group to develop specific recommendations for future ALI/ARDS research. Improved understanding of disease heterogeneity through use of evolving biologic, genomic, and genetic approaches should provide major new insights into pathogenesis of ALI. Cellular and molecular methods combined with animal and clinical studies should lead to further progress in the detection and treatment of this complex disease.