Improving pulse sequences for 3D diffusion-ordered NMR spectroscopy: 2DJ-IDOSY
Improving pulse sequences for 3D diffusion-ordered NMR spectroscopy: 2DJ-IDOSY
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DOI：
10.1021/ac049174f
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发表时间：
2004-09-15
影响因子：
7.4
通讯作者：
Morris, GA
中科院分区：
文献类型：
--
作者：
Nilsson, M;Gil, AM;Morris, GA
提出了一种用于3D DOSY实验2DJ-DOSY的改进脉冲序列，该脉冲序列使用母体2DJ光谱序列（2DJ-IDOSY）内部的扩散编码。的扩散编码脉冲被用来执行所需的相干转移路径，减少了至少4倍的最小实验时间，相比现有的技术，和大约一倍的信噪比的小分子。新的序列是一个简单的混合物上，并在一个复杂的样品具有高的动态范围（波特酒）。内扩散编码的原理可以应用于一系列其他3D DOSY实验。
An improved pulse sequence for the 3D DOSY experiment 2DJ-DOSY, using diffusion encoding internal to the parent 2DJ spectroscopy sequence (2DJ-IDOSY), is presented. The diffusion-encoding pulses are used to enforce the desired coherence transfer pathway, reducing the minimum experimental time by at least a factor of 4, as compared to existing techniques, and approximately doubling the signal-to-noise ratio for small molecules. The new sequence is demonstrated on a simple mixture and on a complex sample with a high dynamic range (port wine). The principle of internal diffusion encoding can be applied with profit to a range of other 3D DOSY experiments.