Comparison of serum concentrations of C-reactive protein, TNF-α, and interleukin 6 between elderly Korean women with normal and impaired glucose tolerance
Comparison of serum concentrations of C-reactive protein, TNF-α, and interleukin 6 between elderly Korean women with normal and impaired glucose tolerance
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DOI：
10.1016/j.diabres.2003.10.007
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发表时间：
2004-05-01
影响因子：
5.1
通讯作者：
Baik, SH
中科院分区：
文献类型：
--
作者：
Choi, KM;Lee, J;Baik, SH
本研究旨在比较糖耐量正常（NGT）和糖耐量受损（IGT）受试者之间的促炎细胞因子浓度，如白细胞介素6 （IL-6）、肿瘤坏死因子α (tnf - α)以及急性期蛋白，如c反应蛋白（CRP）。本研究的目的是验证促炎细胞因子诱导的急性期反应是否是韩国老年女性2型糖尿病的致病机制。在韩国首尔，共有1737名60岁以上的老年受试者参加了一项基于人口的研究（SWS study 1999）。其中，随机选取年龄在60 ~ 89岁之间的非吸烟、非糖尿病女性受试者232人，进行相互比较。IGT患者的血清高敏CRP （hs-CRP）浓度高于糖耐量正常的患者（中位数为1.2 vs 0.9, P < 0.05）。此外，血清hs-CRP浓度与代谢综合征的许多成分之间的关系被检测到。然而，血清促炎细胞因子IL-6或tnf - α浓度在IGT受试者中既没有增加，也与代谢综合征的成分密切相关。以hs-CRP为因变量，采用逐步选择法进行多元回归分析，发现白细胞（WBC）计数、体重指数（BMI）、空腹胰岛素、负荷后2 h葡萄糖、红细胞压积和低密度脂蛋白胆固醇为显著自变量。我们的研究证实，在韩国老年妇女中，急性期反应的增加与糖耐量受损和代谢综合征有关。然而，在我们对韩国老年妇女的研究中，促炎细胞因子诱导的全身性炎症是2型糖尿病发病前的一种早期代谢缺陷的假设并未得到支持。2003爱思唯尔爱尔兰有限公司版权所有。
This study was performed to compare concentrations of pro-inflammatory cytokines, such as interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) as well as acute-phase protein, such as C-reactive protein (CRP) between subjects with normal glucose tolerance (NGT) and impaired glucose tolerance (IGT). The purpose of this study was to verify whether the pro-inflammatory cytokine-induced acute-phase response is a pathogenic mechanism in type 2 diabetes in elderly Korean women. A total of 1737 elderly subjects aged over 60 years participated in a population based study in Seoul, Korea (SWS Study 1999). Amongst them, a total of 232 non-smoking and non-diabetic female subjects aged 60-89 years was randomly selected and compared with each other. Higher serum high-sensitivity CRP (hs-CRP) concentrations were shown in subjects with IGT than those with normal glucose tolerance (median 1.2 versus 0.9, P < 0.05). Moreover, a relationship between serum hs-CRP concentrations and many components of the metabolic syndrome were detected. Serum pro-inflammatory cytokine IL-6 or TNF-alpha concentrations, however, were neither increased in subjects with IGT nor closely correlated with the components of the metabolic syndrome. In multiple regression analysis with stepwise selection method using hs-CRP as a dependent variable, it was found that white blood cell (WBC) counts, body mass index (BMI), fasting insulin, post-load 2 h glucose, hematocrit and LDL cholesterol were significant independent variables. Our study confirms that increased acute-phase reaction is associated with impaired glucose tolerance and the metabolic syndrome in elderly Korean women. However, the hypothesis that pro-inflammatory cytokine-induced systemic inflammation is an early metabolic defect prior to onset of type 2 diabetes, is not supported in our study of elderly Korean women. (C) 2003 Elsevier Ireland Ltd. All rights reserved.