Developmental analysis of the wing disc in the mutant engrailed of Drosophila melanogaster.
Developmental analysis of the wing disc in the mutant engrailed of Drosophila melanogaster.
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DOI：
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发表时间：
1972-09
期刊：
影响因子：
3.3
通讯作者：
A. Garcı́a-Bellido;P. Santamaria
中科院分区：
文献类型：
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作者：
A. Garcı́a-Bellido;P. Santamaria
渐进式(EN)突变导致背侧间胸间盘的后部结构转变为同一间盘前部特有的结构。在所有胸椎节段的背侧和腹侧结构中也发现了类似的前后重复结构。-EN与其他模式突变体的遗传组合已经显示出它们对后翼模式的协同效应。-对EN翼盘的克隆分析表明，EN以一种特有的方式影响其发育。通过诱导有丝分裂重组，EN(+)细胞发生遗传变化，随后发生相应的转化，除非它在分化前发生一些细胞分裂。-EN后翼盘细胞在聚集体中与正常前翼盘细胞呈正亲缘关系。-EN(+)基因座控制翼盘发育的作用方式进行了讨论。
The engrailed (en) mutation leads to the transformation of the posterior structures of the dorsal mesothoracic disc into those characteristic of the anterior region of the same disc. Similar posterior-anterior duplications have been detected in dorsal as well as ventral structures of all the thoracic segments. -Genetic combinations of en with other pattern mutants have shown their synergistic effect on the posterior wing pattern.-A clonal analysis of the en wing disc shows that en affects its development in a characteristic way. The genetic change, by induced mitotic recombination, of en(+) into en cells is followed by the corresponding transformation, except when it takes place some cell divisions prior to differentiation.-The en posterior wing disc cells show positive affinities with normal anterior wing disc cells in aggregates.-The mode of action of the en(+) locus controlling wing disc development is discussed.