Triaxial Electrospun Nanofiber Membranes for Controlled Dual Release of Functional Molecules
Triaxial Electrospun Nanofiber Membranes for Controlled Dual Release of Functional Molecules
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DOI：
10.1021/am402376c
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发表时间：
2013-08-28
影响因子：
9.5
通讯作者：
Steckl, Andrew J.
中科院分区：
文献类型：
--
作者：
Han, Daewoo;Steckl, Andrew J.
利用三轴结构的纳米纤维构建了一种新型的双给药系统，分别将模型药物分别装载在纤维的鞘和芯中，从而提供了不同的释药曲线。制备了含有多种材料(PCL、聚己内酯；PVP、聚乙烯吡咯烷酮)的均匀、同轴和三轴纤维。用两种颜色的染料(KAB和KAU)模拟药物释放曲线，用光吸收法测量其在生理溶液中的释放量随时间的变化。为了达到80%的包覆染料从芯部释放的水平，具有PCL中间层的三轴纤维的释放速度大约是同轴纤维的24倍。同时，三轴纤维的吸湿鞘层提供了与传统单纤维和同轴纤维一样高的第二种染料的初始猝发释放(在一小时内类似于80%)。三轴纤维膜为短期治疗提供了从外层的快速释放，为长期治疗提供了从纤维芯的持续释放。内芯和外鞘之间的中间层起着屏障的作用，防止芯层的淋溶，当膜用于湿法应用时，这一点尤其重要。三轴/多轴电纺纳米纤维膜的形成将使两种不同药物从一个膜中释放出不同的轮廓，从而极大地有利于生物医学的应用。
A novel dual drug delivery system is presented using triaxial structured nanofibers, which provides different release profiles for model drugs separately loaded in either the sheath or the core of the fiber. Homogenous, coaxial and triaxial fibers containing a combination of materials (PCL, polycaprolactone; PVP, polyvinylpyrrolidone) were fabricated. The drug release profiles were simulated using two color dyes (KAB, keyacid blue; KAU, keyacid uranine), whose release in physiological solution was measured using optical absorption as a function of time. To reach the level of 80% release of encapsulated dye from core, triaxial fibers with a PCL intermediate layer exhibited a similar to 24x slower release than that from coaxial fibers. At the same time, the hygroscopic sheath layer of the triaxial fibers provided an initial burst release (similar to 80% within an hour) of a second dye as high as that from conventional single and coaxial fibers. The triaxial fiber membrane provides both a quick release from the outer sheath layer for short-term treatment and a sustained release from the fiber core for long-term treatment. The intermediate layer between inner core and outer sheath acts as a barrier to prevent leaching from the core, which can be especially important when the membranes are used in wet application. The formation of tri/multiaxially electrospun nanofibrous membranes will be greatly beneficial for biomedical applications by enabling different release profiles of two different drugs from a membrane.