Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features.
Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features.
复制标题
微粒体细胞色素 P450 2C5：与微生物 P450 的比较和独特功能。
DOI：
10.1016/s0162-0134(00)00102-1
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发表时间：
2000
影响因子：
3.9
通讯作者：
McRee,DE
中科院分区：
文献类型：
--
作者：
Williams,PA;Cosme,J;Sridhar,V;Johnson,EF;McRee,DE
虽然微粒体P450代表了大多数P450，但只有微生物P450适合于晶体结构解决方案。我们最近首次解析了兔微粒体孕酮羟化酶P450（2C5）的晶体结构。我们讨论了与现有的微生物P450结构的蛋白质的共同特点和基于微生物结构的哺乳动物P450同源建模的局限性。独特的功能，涉及膜，基板和细胞色素P450还原酶的相互作用进行了讨论。
Although microsomal P450s represent the majority of P450s, only microbial P450s have been amenable to crystal structure solution. We have recently solved the first crystal structure of a microsomal P450, 2C5, a progesterone hydroxylase from rabbit. We discuss the features of the protein in common with existing structures of microbial P450s and limitations of homology modeling mammalian P450s based on the microbial structures. Unique features involving membrane, substrate and cytochrome P450 reductase interactions are also discussed.