Phytochemical profile of the stems of Aeonium lindleyi
Phytochemical profile of the stems of Aeonium lindleyi
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DOI：
10.1590/s0102-695x2012005000037
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发表时间：
2012-06-01
期刊：
影响因子：
--
通讯作者：
Kennedy, María L.
中科院分区：
文献类型：
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作者：
Kennedy, María L.
Aeonium是一种富含酚类和萜类化合物的植物，广泛应用于金丝雀民间医药。本课题是在研究Macaronesian地区植物活性成分的基础上，对Aeonium lindleyi Webb & Berthel.茎的化学成分进行了研究。景天科用索氏提取器对该植物风干切碎的茎进行乙醇提取，提取物经硅胶柱层析分离，得到16个已知化合物，包括1个甾醇，4个羽扇烷三萜和11个酚类化合物。它们的结构通过H-1-和C-13-NMR光谱研究和它们的光谱数据与文献值的比较来阐明。这两组分离的代谢物因其不同的生物活性而闻名，它们被描述为抗氧化剂、细胞毒性、抗炎。我们的研究结果有助于对A. Lindleyi作为生物活性化合物的潜在来源。
Aeonium species are plants rich in phenols and terpenoids and have been widely used in the Canary folk medicine. Following our project concerning bioactive compounds from Macaronesian region, a phytochemical study was carried out to investigate the constituents of the stems of Aeonium lindleyi Webb & Berthel., Crassulaceae. Air dried and chopped stems of this plant were extracted with ethanol in a Soxhlet apparatus and the total extract was chromatographed on silica gel to afford sixteen known compounds including, one sterol, four lupane triterpenes and eleven phenolic compounds. Their structures were elucidated by means of H-1-and C-13-NMR spectroscopic studies and comparison of their spectral data with values in the literature. Both group of isolated metabolites are known by their diverse biological activities and they have been described as antioxidant, cytotoxic, anti-inflammatory. Our results contribute to the knowledge of A. lindleyi as a potential source of bioactive compounds.