Genetic changes that accompanied shifts of low pathogenic avian influenza viruses toward higher pathogenicity in poultry.
Genetic changes that accompanied shifts of low pathogenic avian influenza viruses toward higher pathogenicity in poultry.
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DOI：
10.4161/viru.25710
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发表时间：
2013-08-15
期刊：
影响因子：
5.2
通讯作者：
Mettenleiter TC
中科院分区：
文献类型：
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作者：
Abdelwhab el-SM;Veits J;Mettenleiter TC
H5和H7亚型禽流感病毒（AIV）在家禽中表现出两种不同的致病型：低致病性（LP）毒株感染导致最小的健康干扰，如果有的话，而高致病性（HP）毒株则导致严重的发病率和死亡率。H5和H7亚型的LPAIV可自发变异为HPAIV。已知由HPAIV引起的10次暴发是在家禽中传播前体LPAIV之前。其中3例由H5N2亚型引起，7例涉及H7亚型与N1、N3或N7的结合。在此，我们回顾了这些暴发，并总结了在自然条件下导致LPAIV转化为HPAIV的遗传变化。在这些爆发中直接发现的突变更有可能与AIV的毒力、发病机制和早期适应有关。
Avian influenza viruses (AIV) of H5 and H7 subtypes exhibit two different pathotypes in poultry: infection with low pathogenic (LP) strains results in minimal, if any, health disturbances, whereas highly pathogenic (HP) strains cause severe morbidity and mortality. LPAIV of H5 and H7 subtypes can spontaneously mutate into HPAIV. Ten outbreaks caused by HPAIV are known to have been preceded by circulation of a predecessor LPAIV in poultry. Three of them were caused by H5N2 subtype and seven involved H7 subtype in combination with N1, N3, or N7. Here, we review those outbreaks and summarize the genetic changes which resulted in the transformation of LPAIV to HPAIV under natural conditions. Mutations that were found directly in those outbreaks are more likely to be linked to virulence, pathogenesis, and early adaptation of AIV.