Laser-triggered repetitive fluorescein angiography.
Laser-triggered repetitive fluorescein angiography.
复制标题
激光触发重复荧光素血管造影。
DOI：
10.1016/s0161-6420(92)32007-x
复制
发表时间：
1992
期刊：
影响因子：
13.7
通讯作者：
Vo,K
中科院分区：
文献类型：
--
作者：
Khoobehi,B;Peyman,GA;Vo,K
脂质体封装的荧光染料已被改变，可以在单次激光照射后进行完整的眼底血管造影。通过将出现在视盘神经头的视网膜动脉暴露在激光能量下，在视网膜的所有四个象限中同时引发染料释放，没有脉络膜荧光，从而可以可视化视网膜微循环。由于染料释放量有限，再循环不会增加背景荧光。该过程可以毫不延迟地重复多次，并获得一致的结果。将激光光斑尺寸增加到 1.5 毫米，可以在 0.5 J/cm2 至 3.4 J/cm2 的能量密度下实现一致的染料释放。这种改进将允许在灵长类动物中直接比较该技术和传统的荧光素血管造影术。传递到视网膜的激光能量低于视神经可以耐受的建议水平。
Liposome-encapsulated fluorescent dye has been altered to allow full fundus angiography after a single laser shot. By exposing the retinal arteries to laser energy where they emerge at the optic disc nerve head, dye release is elicited simultaneously in all four quadrants of the retina, without choroidal fluorescence, allowing visualization of the retinal microcirculation. Because the quantity of dye release is limited, recirculation does not increase background fluorescence. The procedure can be repeated many times without delay with consistent results. Increasing the laser spot size to 1.5 mm allows consistent dye release at energy densities from 0.5 J/cm2to 3.4 J/cm2. This refinement will allow direct comparison in primates of this technique and conventional fluorescein angiography. The laser energy delivered to the retina is below suggested levels that may be tolerated by the optic nerve.