An index of substitution saturation and its application
An index of substitution saturation and its application
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DOI：
10.1016/s1055-7903(02)00326-3
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发表时间：
2003-01-01
影响因子：
4.1
通讯作者：
Wang, Y
中科院分区：
文献类型：
--
作者：
Xia, XH;Xie, Z;Wang, Y
我们引入了一个新的指标来衡量一组比对的核苷酸序列中的取代饱和度。该指数基于信息论中的熵概念。通过计算机仿真，得到了不同序列长度、不同OTU数和不同拓扑结构下的临界指数。临界值使研究人员能够快速判断一组比对序列在遗传学中是否有用。我们说明了指数，通过将其应用到延伸因子-1 α基因的对齐序列的分析，最初用于解决主要节肢动物群体的深源性。该方法已在DAMBE中实现。(C)2002 Elsevier Science（美国）。All rights reserved.
We introduce a new index to measure substitution saturation in a set of aligned nucleotide sequences. The index is based on the notion of entropy in information theory. We derive the critical values of the index based on computer simulation with different sequence lengths, different number of OTUs and different topologies. The critical value enables researchers to quickly judge whether a set of aligned sequences is useful in phylogenetics. We illustrate the index by applying it to an analysis of the aligned sequences of the elongation factor-1alpha gene originally used to resolve the deep phylogeny of major arthropod groups. The method has been implemented in DAMBE. (C) 2002 Elsevier Science (USA). All rights reserved.