Boiled coffee fails to raise serum cholesterol in hamsters and rats
Boiled coffee fails to raise serum cholesterol in hamsters and rats
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DOI：
10.1079/bjn19960081
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发表时间：
1996-11-01
影响因子：
3.6
通讯作者：
Katan, MB
中科院分区：
文献类型：
--
作者：
Beynen, AC;WeustenvanderWouw, MPME;Katan, MB
煮熟的咖啡含有脂类化合物咖啡醇和咖啡豆醇，它们会强烈提高人体的胆固醇水平。这些脂质被纸过滤器保留。为了寻找咖啡脂质对血清胆固醇浓度影响的动物模型，我们给仓鼠（auratus Mesocricetus）和大鼠喂食由纯化基础饲料和开水、未过滤的煮咖啡或过滤的煮咖啡组成的捣碎饲料。在8周的喂养期后，未过滤的煮咖啡对仓鼠和大鼠的血清总胆固醇和甘油三酯浓度没有统计学上的显著影响。血清胆固醇水平确实对饮食中添加胆固醇和/或饱和脂肪酸有可预测的反应。未经过滤的煮咖啡对仓鼠和大鼠的影响，与先前报道的对人类的影响相比，不能用剂量、治疗时间、给药方式或统计能力不足来解释。结论是，仓鼠和大鼠对未过滤的煮咖啡不敏感，因此不适合作为研究其高胆固醇降血脂作用的模型。
Boiled coffee contains the lipid compounds cafestol and kahweol, which raise cholesterol strongly in man. These lipids are retained by paper filters. In a search for an animal model for the effect of coffee lipids on serum cholesterol concentrations, we fed hamsters (Mesocricetus auratus) and rats on mash diets consisting of a purified base diet and either boiled water, unfiltered boiled coffee or filtered boiled coffee. After a feeding period of 8 weeks there was no statistically significant effect of unfiltered boiled coffee on serum total cholesterol and triacylglycerol concentrations in either the hamsters or the rats. The level of serum cholesterol did respond predictably to the addition of cholesterol and/or saturated fatty acids to the diet. The lack of effect of unfiltered boiled coffee in the hamsters and the rats, when compared with the previously reported activity in humans, could not be explained by dosage, duration of treatment, mode of administration or by insufficient statistical power. It is concluded that hamsters and rats are insensitive to unfiltered boiled coffee and thus are unsuitable models for investigating its hypercholesterolaemic effect.