INTRACEREBRAL POTENTIALS TO RARE TARGET AND DISTRACTER AUDITORY AND VISUAL-STIMULI .2. MEDIAL, LATERAL AND POSTERIOR TEMPORAL-LOBE
INTRACEREBRAL POTENTIALS TO RARE TARGET AND DISTRACTER AUDITORY AND VISUAL-STIMULI .2. MEDIAL, LATERAL AND POSTERIOR TEMPORAL-LOBE
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DOI：
10.1016/0013-4694(95)98475-n
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发表时间：
1995-04-01
期刊：
影响因子：
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通讯作者：
BIRABEN, A
中科院分区：
文献类型：
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作者：
HALGREN, E;BAUDENA, P;BIRABEN, A
在39例患者的颞叶内侧、外侧和后部共1221个部位记录了事件相关电位。植入深部电极约4天，以便在手术治疗前定位癫痫发作起源。受试者接受目标和非目标稀有刺激的听觉辨别任务。在某些情况下，目标，分散和频繁的音调是完全平衡的音高和音量块。一些受试者还接受了类似的视觉辨别任务，或听觉任务，其中罕见的目标事件是省略音调，或在一系列交替音调中重复音调。在某些受试者中，相同的听觉刺激被传递，但患者在阅读时忽略了它们，记录了一个复杂的场，指示具有重叠时间过程的多个分量，任务相关性和生成器。两个一般模式可以区分的基础上，他们的波形，lavitation和任务相关。在颞极、颞中、海马旁后回和梭状回等部位，常观察到一个尖峰在220-320-420毫秒的负-正-负三相波形。此波振幅较小，弥散，极性很少反转。它是多模态的，但最突出的听觉刺激，似乎仍然当刺激被忽略，并不明显，重复的话和面孔。第二个宽的，通常是双相的，峰值约为380毫秒的波形产生于海马体中，海马体是上级颞沟的一个有限区域，（通过推断）在前基底颞叶（可能是鼻皮质）中。这种波形具有大振幅，通常高度聚焦，并且可以在短距离内反转。它相当于视觉和听觉刺激，当刺激被忽略时大大减少，并且也被重复的单词和面孔所唤起。在此波形之前是一个非模态特异性负波，可能产生于鼻腔皮层，和视觉特异性负波在下颞叶皮层。早期三相模式可能体现了弥漫性非特异性定向反应，也反映在头皮P3 a。晚相模式可能体现了认知闭合，这也反映在头皮P3 b或晚阳性成分中。
Event-related potentials were recorded from 1221 sites in the medial, lateral and posterior aspects of the temporal lobe in 39 patients. Depth electrodes were implanted for about 4 days in order to localize seizure origin prior to surgical treatment. Subjects received an auditory discrimination task with target and non-target rare stimuli. In some cases, the target, distracting and frequent tones were completely balanced across blocks for pitch and volume. Some subjects also received an analogous visual discrimination task, or auditory tasks in which the rare target event was the omission of a tone, or the repetition of a tone within a series of alternating tones. In some subjects, the same auditory stimuli were delivered but the patient ignored them while reading.A complex field was recorded, indicating multiple components with overlapping time-courses, task correlates and generators. Two general patterns could be distinguished on the basis of their waveforms, latencies and task correlates. In the temporal pole and some middle temporal, posterior parahippocampal and fusiform gyrus sites, a sharp triphasic negative-positive-negative waveform with peaks at about 220-320-420 msec was usually observed. This wave was of relatively small amplitude and diffuse, and seldom inverted in polarity. It was multimodal but most prominent to auditory stimuli, appeared to remain when the stimuli were ignored, and was not apparent to repeated words and faces. A second broad, often monophasic, waveform peaking at about 380 msec was generated Ln the hippocampus, a limited region of the superior temporal sulcus, and (by inference) in the anterobasal temporal lobe (possible rhinal cortex). This waveform was of large amplitude, often highly focal, and could invert over short distances. It was equal to visual and auditory stimuli, was greatly diminished when the stimuli were ignored, and was also evoked by repeating words and faces. Preceding this waveform was a non-modality-specific negativity, possibly generated in rhinal cortex, and a visual-specific negativity in inferotemporal cortex.The early triphasic pattern may embody a diffuse non-specific orienting response that is also reflected in the scalp P3a. The late monophasic pattern may embody the cognitive closure that is also reflected in the scalp P3b or late positive component.