A highly potent insulin: des-(B26-B30)-[AspB10,TyrB25-NH2]insulin(human).
A highly potent insulin: des-(B26-B30)-[AspB10,TyrB25-NH2]insulin(human).
复制标题
高效胰岛素：des-(B26-B30)-[AspB10,TyrB25-NH2]胰岛素（人）。
DOI：
10.1073/pnas.86.2.458
复制
发表时间：
1989
影响因子：
11.1
通讯作者：
Katsoyannis,PG
中科院分区：
文献类型：
--
作者：
Schwartz,GP;Burke,GT;Katsoyannis,PG
一种包含两种不同结构修饰的胰岛素类似物已被合成并评估其生物活性，每种结构修饰均独立地增加胰岛素活性。类似物 des-(B26-B30)-[AspB10,TyrB25-NH2] 胰岛素是迄今为止描述的最有效的胰岛素类似物；它的活性比天然胰岛素高 11 至 13 倍。讨论了有关胰岛素受体结合域的发现。
An insulin analogue that embodies two distinct structural modifications, each of which independently increases insulin activity, has been synthesized and evaluated for biological activity. The analogue, des-(B26-B30)-[AspB10,TyrB25-NH2]insulin is the most potent insulin analogue yet described; it displays an 11- to 13-fold higher activity than natural insulin. The findings are discussed with regard to the receptor-binding domains of insulin.