EVIDENCE FOR CYCLIC DEVELOPMENT AND SHORT-LIVED MATURITY IN GAMETOCYTES OF PLASMODIUM-FALCIPARUM
EVIDENCE FOR CYCLIC DEVELOPMENT AND SHORT-LIVED MATURITY IN GAMETOCYTES OF PLASMODIUM-FALCIPARUM
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DOI：
10.1016/0035-9203(71)90036-8
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发表时间：
1971-01-01
影响因子：
2.2
通讯作者：
GAMMAGE, K
中科院分区：
文献类型：
--
作者：
HAWKING, F;WILSON, ME;GAMMAGE, K
先前的研究表明，许多疟疾寄生虫的配子细胞只能在很短的时间内(6-10小时)感染蚊子。感染期被定在载体进食的夜间，这是因为从Merozpite发育配子细胞的时间比血液中(通常)同步的无性周期长约6小时[HAWKINGet等人，This Bullet，1969，v66，abstr]。[2063]恶性疟原虫配子体细胞不寻常，因为它们的成熟非常慢(大约12天)，这项调查的目的是确定它们的发育到成熟是否仍然有节奏。5名自然感染的西非(冈比亚)儿童显示配子体，每4小时拍摄一次血片，持续4天。从脱鞭毛和雌、雄配子体的数目来看，配子体发育到成熟有一个48小时的节律。恶性疟原虫。将配子体分为5个发育阶段，从无性分裂中分离出一窝配子体，雌雄配子体同时成熟。关于疟原虫周期性发育的性质和控制的讨论，包括一些关于相当不寻常的发育的有趣观点。恶性疟原虫配子细胞。
Previous studies have shown that the gametocytes of many malaria parasites are able to infect mosquitoes for only a short period (6-10 hours). The period of infectivity is timed to occur at night when the vectors feed, the timing being achieved because the development of the gametocytes from merozpites takes approximately 6 hours longer than the (usually) synchronized asexual cycle in the blood [HAWKINGet al., thisBulletin, 1969, v. 66, abstr. 2063].Plasmodium falciparumgametocytes are unusual since they mature only very slowly (in about 12 days) and the object of this investigation was to establish whether there was nevertheless a rhythm in their development to maturity.Blood films were taken every 4 hours for 4 days from each of 5 naturally infected West African (Gambian) children who showed gametocytes. From counts of the numbers of exflagellations and of male and female gametocytes, there were strong indications of a 48-hour rhythm in development of the gametocytes to maturity.Gametocyte counts were made on anAotusmonkey infected withP. falciparum. The gametocytes were classified into five stages of development and it appeared that there was one brood of gametocytes liberated from asexual schizogonies on one or perhaps two days, with the male and female gametocytes maturing at the same time.The discussion on the nature and control of cyclical development of plasmodia includes some interesting ideas about the rather unusual development ofP. falciparumgametocytes.G. A. T. Targett.