Shimalactone A, a novel polyketide, from marine-derived fungus Emericella variecolor GF10
Shimalactone A, a novel polyketide, from marine-derived fungus Emericella variecolor GF10
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DOI：
10.1016/j.tet.2005.05.105
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发表时间：
2005-08-15
期刊：
影响因子：
2.1
通讯作者：
Kobayashi, M
中科院分区：
文献类型：
--
作者：
Wei, H;Itoh, T;Kobayashi, M
Shimalactone A（1）是从一种海洋真菌Emericella variecolor GF 10中分离得到的一种新型聚酮化合物，其结构为双环[4.2.0]辛烯和氧杂双环[2.2.1]庚烷。通过对1及其衍生物的2D NMR和X-射线晶体学分析，推测了1的立体结构。1的绝对结构通过将CD苯甲酸烯丙酯规则应用于1的苯甲酸酯衍生物来确定。10 μ g/mL的Shimalactone A（1）可诱导神经母细胞瘤Neuro 2A细胞的轴突发生。(c)2005爱思唯尔有限公司保留所有权利。
Shimalactone A (1), a novel polyketide having bicyclo[4.2.0]octadiene and oxabicyclo[2.2.1]heptane units, was isolated from a cultured marine fungus of Emericella variecolor GF10. The stereo structure of 1 was deduced from 2D NMR and X-ray crystallographic analyses of 1 and its derivatives. The absolute structure of 1 was determined by application of the CD allylic benzoate rule to the benzoate derivative of 1. Shimalactone A (1) induced neuritogenesis at 10 mu g/mL against neuroblastoma Neuro 2A cells. (c) 2005 Elsevier Ltd. All rights reserved.